T-cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder and can cooccur in the context of pure red cell aplasia (PRCA). The aim of the current study was to analyze the signal transducer and activator of transcription 3 (STAT3) mutation status and its clinical significance in T-LGLL. We found STAT3 mutations in 21.4% of patients with T-LGLL. High beta 2-MG (beta 2-microglobulin) levels (P = 0.005), neutropenia (P = 0.018) and PRCA (P = 0.001) all displayed a significant association with STAT3 mutations. In univariate analysis, treatment-free survival (TFS) was affected by STAT3 mutation status (P = 0.008) and beta 2-MG (P = 0.006). Our results demonstrate the remarkable correlation of STAT3 mutation with PRCA, neutropenia and beta 2-MG.
基金：
National Natural Science Foundation of China [30871104, 30971296, 81170485, 81170488]; Natural Science Foundation of Jiangsu Province [BK2010584]; Key Projects of Health Department of Jiangsu Province [K201108]; Jiangsu Province's Medical Elite Program [RC2011169]; National Public Health Grand Research Foundation [201202017]; Priority Academic Program Development of Jiangsu Higher Education Institute [JX10231801]; Program for Development of Innovative Research Teams in the First Affiliated Hospital of Nanjing Medical University; Project of National Key Clinical Specialty
第一作者单位：[1]Nanjing Med Univ, Jiangsu Prov Hosp, Affiliated Hosp 1, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Qiu Zhi-Yuan,Fan Lei,Wang Li,et al.STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia[J].JOURNAL OF HEMATOLOGY & ONCOLOGY.2013,6:doi:10.1186/1756-8722-6-82.
APA：
Qiu, Zhi-Yuan,Fan, Lei,Wang, Li,Qiao, Chun,Wu, Yu-Jie...&Li, Jian-Yong.(2013).STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia.JOURNAL OF HEMATOLOGY & ONCOLOGY,6,
MLA：
Qiu, Zhi-Yuan,et al."STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia".JOURNAL OF HEMATOLOGY & ONCOLOGY 6.(2013)
医学