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KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure

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收录情况： ◇ SCIE

作者：
chen,tao[1] * ; zhu,lin[1] ; zhou,yaoyong[1] ; pi,bin[1] ; liu,xiaojuan[1] ; deng,guohong[2] ; zhang,rong[2] ; wang,yuming[2] ; wu,zeguang[1] ; han,meifang[1] ; luo,xiaoping[3,*1] ; ning,qin[1,*2] ;
单位： [1]Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China [2]Department of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing, PR China [3]Department of Pediatric Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
出处：
DOI： 10.1016/j.clim.2012.12.013
ISSN：

关键词： KCTD9 Natural killer cell HBV Virus induced liver injury Acute on chronic liver failure

摘要：
We explored the expression of a newly identified potassium channel tetramerisation domain containing 9 (KCTD9) protein in 113 blood and 81 liver samples, from patients with mild chronic hepatitis B (CHB) or HBV-induced acute-on-chronic liver failure (HBV-ACLF). KCTD9 was highly expressed in peripheral and hepatic NK cells from HBV-ACLF patients compared with mild CHB patients, and this correlated positively with the severity of liver injury. The role of KCTD9 was further investigated in NK92 cells in vitro. KCTD9 overexpressed NK92 cells exhibited a marked increase in CD69 expression, cytotoxicity, IFN-gamma secretion and a significant decrease in NKG2A receptor expression. Inhibition of KCTD9 by shRNA resulted in reduced cytotoxic function. These results suggest the involvement of KCTD9 in NK cell activation and provide additional insight into a potential therapeutic target for molecular manipulation for HBV-ACLF patients. (C) 2013 Elsevier Inc. All rights reserved.

基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC 81030007]; National Key Basic Research Program of ChinaNational Basic Research Program of China [2007CB512900]; Program for Innovative Research Team of Chinese Ministry of Education [IRT1131]; National Health Clinical Key Project of Ministry [(2010)439]; National Natural Science Funds for Young Scholar [NSFC 81100308]

基金编号： NSFC 81030007 2007CB512900 IRT1131 (2010)439 NSFC 81100308

语种：
外文
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中科院(CAS)分区：
出版当年[2012]版：
大类 | 2 区 医学
小类 | 3 区 免疫学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
JCR分区：
出版当年[2011]版：
Q2 IMMUNOLOGY
最新[2023]版：
Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者：
第一作者单位： [1]Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
通讯作者：
通讯机构： [3]Department of Pediatric Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China [*1]Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, PR China. [*2]Department of Infectious Disease, Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, PR China.
推荐引用方式(GB/T 7714)：
chen tao,zhu lin,zhou yaoyong,et al.KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure[J].CLINICAL IMMUNOLOGY.2013,146(3):207-216.doi:10.1016/j.clim.2012.12.013.
APA：
chen,tao,zhu,lin,zhou,yaoyong,pi,bin,liu,xiaojuan...&ning,qin.(2013).KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure.CLINICAL IMMUNOLOGY,146,(3)
MLA：
chen,tao,et al."KCTD9 contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure".CLINICAL IMMUNOLOGY 146..3(2013):207-216

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