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Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report

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单位: [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Pathol,Tongji Hosp,Wuhan 430030,Peoples R China [2]Zhongshan Hosp Hubei Prov, Dept Oncol, Wuhan 430000, Peoples R China
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关键词: Thymoma micronodular ectopic langerhans cell

摘要:
Ectopic micronodular thymoma (MNT) is a rare tumor. We described a 76-year-old woman, who was referred to our institutional for a mass in the left cervical region. The Magnetic Resonance Imaging (MRI) scan showed a 3.7 cm x 1.7 cm x 2.0 cm mass. The neoplasm was composed of epithelial tumor cells arranged in a micronodular growth pattern set in a stroma showing lymphoid hyperplasia with germinal centers. Immunohistochemical studies showed that the neoplastic epithelial cells were reactive for AE1/AE3, CK5/6, P63, and the lymphoid component to be of mixed B-and immature T-cell lineage. Langerhans cells were confirmed within epithelial nodules for the first time with langerin, S-100, CD1a expression. We report a case of cervical ectopic MNT to emphasize the langerhans cells proliferation and the histopathologic features and differential diagnosis of the rare lesion to promote a better and broader understanding of this less understood subject.

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出版当年[2013]版:
大类 | 4 区 医学
小类 | 3 区 病理学 4 区 肿瘤学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 病理学
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出版当年[2012]版:
Q2 PATHOLOGY Q3 ONCOLOGY
最新[2024]版:
Q4 ONCOLOGY Q4 PATHOLOGY

影响因子: 最新[2024版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

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第一作者单位: [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Pathol,Tongji Hosp,Wuhan 430030,Peoples R China
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通讯机构: [1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Pathol,Tongji Hosp,Wuhan 430030,Peoples R China [*1]Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Pathol, 1095 Jiefang Dadao, Wuhan 430030, Peoples R China
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