Ectopic micronodular thymoma (MNT) is a rare tumor. We described a 76-year-old woman, who was referred to our institutional for a mass in the left cervical region. The Magnetic Resonance Imaging (MRI) scan showed a 3.7 cm x 1.7 cm x 2.0 cm mass. The neoplasm was composed of epithelial tumor cells arranged in a micronodular growth pattern set in a stroma showing lymphoid hyperplasia with germinal centers. Immunohistochemical studies showed that the neoplastic epithelial cells were reactive for AE1/AE3, CK5/6, P63, and the lymphoid component to be of mixed B-and immature T-cell lineage. Langerhans cells were confirmed within epithelial nodules for the first time with langerin, S-100, CD1a expression. We report a case of cervical ectopic MNT to emphasize the langerhans cells proliferation and the histopathologic features and differential diagnosis of the rare lesion to promote a better and broader understanding of this less understood subject.
第一作者单位:[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Pathol,Tongji Hosp,Wuhan 430030,Peoples R China
通讯作者:
通讯机构:[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Inst Pathol,Tongji Hosp,Wuhan 430030,Peoples R China[*1]Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Pathol, 1095 Jiefang Dadao, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714):
Zhu Pengcheng,Yan Fei,Ao Qilin.Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2014,7(10):7262-7267.
APA:
Zhu, Pengcheng,Yan, Fei&Ao, Qilin.(2014).Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,7,(10)
MLA:
Zhu, Pengcheng,et al."Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7..10(2014):7262-7267