Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P-meta<10(-4)) in 960 EOC cases and 1,799 controls (stage II), and an additional 492 EOC cases and 1,004 controls (stage III). Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P-meta = 1.88 x 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P-meta = 2.62 x 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P-meta = 1.14 x 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P-meta = 8.57 x 10(-7)) (P<0.05 in all three stages). These results may advance our understanding of genetic susceptibility to EOC.
基金：
Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) in China [IRT1076]; National Key Scientific and Technological Project [2011ZX09307-001-04]; National Natural Science Foundation of China [81320108022, 81072363]; Tianjin Science and Technology Committee Foundation [09ZCZDSF04700]; National High Technology Research and Development Program of China [2012AA02A207]; China's Thousand Talents Program recruitment at Fudan University; Tianjin Cancer Institute and Hospital; U.S. National Foundation for Cancer Research
第一作者单位：[1]Tianjin Med Univ, Canc Inst & Hosp, Key Lab Canc Prevent & Therapy Tianjin, Natl Clin Res Ctr Canc,Dept Epidemiol & Biostat, Tianjin 300060, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Kexin,Ma Hongxia,Li Lian,et al.Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women[J].NATURE COMMUNICATIONS.2014,5:doi:10.1038/ncomms5682.
APA：
Chen, Kexin,Ma, Hongxia,Li, Lian,Zang, Rongyu,Wang, Cheng...&Wei, Qingyi.(2014).Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.NATURE COMMUNICATIONS,5,
MLA：
Chen, Kexin,et al."Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women".NATURE COMMUNICATIONS 5.(2014)
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