Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway
Obstructive sleep apnea syndrome (OSAS) is usually associated with multiple cardiovascular disorders, including myocardial hypertrophy. Melatonin protects the heart from damaging conditions. However, whether melatonin alleviates heart damage induced by chronic intermittent hypoxia (CIH) is unknown. We investigated the melatonin-induced protective role of AMPK-regulated autophagy in the myocardium by exposing rats to CIH and treating them with melatonin or saline daily for six weeks. In vivo, CIH induced significant myocardial hypertrophy; this trend was strikingly reversed by melatonin. Moreover, AMPK activation and autophagy was enhanced, and the number of autophagosomes increased. CIH induced apoptosis of cardiomyocytes; this was significantly mitigated by melatonin. In vitro, CIH induced hypertrophic changes in cardiomyocytes; this effect was significantly reversed by melatonin. Autophagy decreased after AMPK inhibition, and we found that autophagy was required for the protective function of melatonin. Our results suggest that melatonin ameliorates cardiac hypertrophy caused by CIH by inducing autophagy via the AMPK pathway and by autophagy-regulated apoptosis. (C) 2015 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of China [81370185, 81070067]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Resp & Crit Care Med, Wuhan 430030, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Resp & Crit Care Med, Wuhan 430030, Peoples R China[*1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Resp & Crit Care Med, 1095 Jiefang Ave, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Xie Sheng,Deng Yan,Pan Yue-ying,et al.Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2015,464(4):975-981.doi:10.1016/j.bbrc.2015.06.149.
APA：
Xie, Sheng,Deng, Yan,Pan, Yue-ying,Wang, Zhi-hua,Ren, Jie...&Liu, Hui-guo.(2015).Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,464,(4)
MLA：
Xie, Sheng,et al."Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 464..4(2015):975-981
