Objective: We investigated the relationship between proteinuria in L-NAME induced preeclampsia and the expression of nephrin and podocin, and the effect of low-molecular-weight-heparin (LMWH) on proteinuria in rats. Methods: We detected nephrin and podocin expression of kidneys of pregnant rats after L-NAME and after LMWH intervening pregnant rats. Results: Glomerular nephrin expression in L-NAME induced preeclampsia significantly decreased, but not podocin. Nephrin was relatively increased after LMWH intervention and this was accompanied by a decrease in proteinuria. Conclusion: We demonstrate that down-regulation of nephrin is involved in L-NAME induced proteinuria, and that LMWH reduces proteinuria by up-regulation of neprhin.
基金：
foundation of National Science and Technology [81200451]; Natural Science Foundation of the Hubei Province Science Technology [QJX2010-6]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan 430000, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Wanlu,Qiao Fuyuan,Liu Haiyi,et al.Low molecular weight heparin improves proteinuria in rats with L-NAME induced preeclampsia by decreasing the expression of nephrin, but not podocin[J].HYPERTENSION IN PREGNANCY.2015,34(1):24-35.doi:10.3109/10641955.2014.951655.
APA：
Liu, Wanlu,Qiao, Fuyuan,Liu, Haiyi,Gong, Xun,Shi, Xinwei...&Wu, Yuanyuan.(2015).Low molecular weight heparin improves proteinuria in rats with L-NAME induced preeclampsia by decreasing the expression of nephrin, but not podocin.HYPERTENSION IN PREGNANCY,34,(1)
MLA：
Liu, Wanlu,et al."Low molecular weight heparin improves proteinuria in rats with L-NAME induced preeclampsia by decreasing the expression of nephrin, but not podocin".HYPERTENSION IN PREGNANCY 34..1(2015):24-35
