CX43 plays a critical role in tumor progression. Previous studies imply that AR pathway may be involved in regulation of CX43. This study was focused on determining the relationship between AR pathway and CX43. The result showed that the expression of CX43 in malignant cells was higher than that in normal cells, and in nonmalignant and malignant cells, not only is the expression level of CX43 different, but the localization of CX43 can also be changed. After androgen stimulation and inhibition of AR pathway, expression of CX43 can also be changed. Thus, AR pathway plays an important role in regulation of CX43 expression in prostate cancer cells. AR may be the upstream signal of CX43.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101927, 81472405]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|3 区生物
小类|3 区生物工程与应用微生物3 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2013]版：
Q4BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Urol,Tongji Med Coll,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Inst Urol,Tongji Hosp,Tongji Med Coll,Wuhan 430030,Hubei,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Urol,Tongji Med Coll,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Inst Urol,Tongji Hosp,Tongji Med Coll,Wuhan 430030,Hubei,Peoples R China
推荐引用方式(GB/T 7714)：
Chen Ruibao,Luan Yang,Liu Zhuo,et al.AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer[J].BIOMED RESEARCH INTERNATIONAL.2015,2015:doi:10.1155/2015/514234.
APA：
Chen, Ruibao,Luan, Yang,Liu, Zhuo,Song, Wen,Wu, Licheng...&Ye, Zhangqun.(2015).AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer.BIOMED RESEARCH INTERNATIONAL,2015,
MLA：
Chen, Ruibao,et al."AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer".BIOMED RESEARCH INTERNATIONAL 2015.(2015)
