个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Gao, Hua[1,2,3,4] * ; Chakraborty, Goutam[3,4] ; Zhang, Zhanguo[3,4,11] ; Akalay, Intissar[3,4] ; Gadiya, Mayur[3,4,5] ; Gao, Yaquan[1,2] ; Sinha, Surajit[3,4] ; Hu, Jian[6] ; Jiang, Cizhong[6] ; Akram, Muzaffar[7] ; Brogi, Edi[7] ; Leitinger, Birgit[8] ; Giancotti, Filippo G.[3,4,9,10] ;
单位： [1]Tongji Univ, Shanghai East Hosp, Res Ctr Translat Med,Metastasis Res Inst, Key Lab Arrhythmias,Minist Educ China,Breast Canc, Shanghai 200092, Peoples R China; [2]Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China; [3]Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA; [4]Mem Sloan Kettering Canc Ctr, Ctr Metastasis Res, Sloan Kettering Inst Canc Res, New York, NY 10065 USA; [5]Cornell Univ, Weill Cornell Grad Sch Med Sci, Sloan Kettering Div, New York, NY 10065 USA; [6]Tongji Univ, Collaborat Innovat Ctr Brain Sci, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China; [7]Mem Hosp, Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA; [8]Imperial Coll London, Natl Heart & Lung Inst, Mol Med Sect, London SW7 2AZ, England; [9]UT MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77054 USA; [10]UT MD Anderson Canc Ctr, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77054 USA; [11]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Peoples R China
出处：
DOI： 10.1016/j.cell.2016.06.009
ISSN：

摘要：
Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKC alpha. The latter kinase phosphorylates and activates JAK2, leading to the activation of STAT3. This non-canonical mechanism of signaling induces the expression of SOX2 and NANOG; sustains the manifestation of cancer stem cell traits; and drives metastatic reactivation in the lung, bone, and brain. Bioinformatic analyses and pathological studies corroborate the clinical relevance of these findings. We conclude that non-canonical DDR1 signaling enables breast cancer cells to exploit the ubiquitous interstitial matrix component collagen I to undergo metastatic reactivation in multiple target organs.

基金：
NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 CA175712, R35 CA197566, P01 CA094060]; Geoffrey Beene Cancer Center of MSKCC; National Basic Research program of China (973 Program)National Basic Research Program of China [2015CB964800]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372840]; One Thousand Talents Program of Shanghai [SH04020]; Foundation for Innovative Research Groups of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81221001]; Program for Professors of Special Appointment at Shanghai Institutions of Higher Learning; China Scholarship CouncilChina Scholarship Council; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, R01CA175712, R01CA175712, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, R35CA197566, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, R35CA197566, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, R35CA197566, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, R01CA175712, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, R35CA197566, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P01CA094060, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P30CA008748, P01CA094060, P30CA008748, P30CA008748, P30CA008748] Funding Source: NIH RePORTER

基金编号： R01 CA175712 R35 CA197566 P01 CA094060 2015CB964800 81372840 SH04020 81221001 P30CA008748 P01CA094060 R01CA175712 R35CA197566

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 1 区 生物
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 生化与分子生物学 1 区 细胞生物学
JCR分区：
出版当年[2014]版：
Q1 CELL BIOLOGY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2024]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者单位： [1]Tongji Univ, Shanghai East Hosp, Res Ctr Translat Med,Metastasis Res Inst, Key Lab Arrhythmias,Minist Educ China,Breast Canc, Shanghai 200092, Peoples R China; [2]Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China; [3]Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA; [4]Mem Sloan Kettering Canc Ctr, Ctr Metastasis Res, Sloan Kettering Inst Canc Res, New York, NY 10065 USA;
通讯作者：
通讯机构： [1]Tongji Univ, Shanghai East Hosp, Res Ctr Translat Med,Metastasis Res Inst, Key Lab Arrhythmias,Minist Educ China,Breast Canc, Shanghai 200092, Peoples R China; [2]Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai 200092, Peoples R China; [3]Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA; [4]Mem Sloan Kettering Canc Ctr, Ctr Metastasis Res, Sloan Kettering Inst Canc Res, New York, NY 10065 USA; [9]UT MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77054 USA; [10]UT MD Anderson Canc Ctr, David H Koch Ctr Appl Res Genitourinary Canc, Houston, TX 77054 USA;
推荐引用方式(GB/T 7714)：
Gao Hua,Chakraborty Goutam,Zhang Zhanguo,et al.Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling[J].CELL.2016,166(1):47-62.doi:10.1016/j.cell.2016.06.009.
APA：
Gao, Hua,Chakraborty, Goutam,Zhang, Zhanguo,Akalay, Intissar,Gadiya, Mayur...&Giancotti, Filippo G..(2016).Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling.CELL,166,(1)
MLA：
Gao, Hua,et al."Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling".CELL 166..1(2016):47-62

资源点击量：622 今日访问量：0 总访问量：452 更新日期：2025-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有：重庆聚合科技有限公司 渝ICP备12007440号-3 地址：重庆市两江新区泰山大道西段8号坤恩国际商务中心16层（401121）