Quantitative Susceptibility Mapping and R2*Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation
单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan, Peoples R China放射科华中科技大学同济医学院附属同济医院[2]Weill Cornell Med Coll, Dept Radiol, 515 East 71th St, New York, NY 10021 USA[3]Weill Cornell Med Coll, Dept Neurol, New York, NY USA[4]Weill Cornell Med Coll, Dept Healthcare Policy & Res, New York, NY USA[5]Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA[6]Cornell Univ, Dept Biomed Engn, Ithaca, NY USA
BACKGROUND BACKGROUND AND PURPOSE: Quantitative susceptibility mapping and R2* are sensitive to myelin and iron changes in multiple sclerosis lesions. This study was designed to characterize lesion changes on quantitative susceptibility mapping and R2* at various gadolinium enhancement stages. MATERIALS AND METHODS: This study included 64 patients with MS with different enhancing patterns in white matter lesions: nodular, shell-like, nonenhancing < 1 year old, and nonenhancing 1-3 years old. These represent acute, late acute, early chronic, and late chronic lesions, respectively. Susceptibility values measured on quantitative susceptibility mapping and R2* values were compared among the 4 lesion types. Their differences were assessed with a generalized estimating equation, controlling for Expanded Disability Status Scale score, age, and disease duration. RESULTS: We analyzed 203 lesions: 80 were nodular-enhancing, of which 77 (96.2%) were isointense on quantitative susceptibility mapping; 33 were shell-enhancing, of which 30 (90.9%) were hyperintense on quantitative susceptibility mapping; and 49 were nonenhancing lesions <1 year old and 41 were nonenhancing lesions 1-3 years old, all of which were hyperintense on quantitative susceptibility mapping. Their relative susceptibility/R2* values were 0.5 +/- 4.4 parts per billion/- 5.6 +/- 2.9 Hz,10.2 +/- 5.4 parts per billion/ -8.0 +/- 2.6 Hz, 20.2 +/- 7.8 parts per billion/-3.1 +/- 2.3 Hz, and 33.2 +/- 8.2 parts per billion/-2.0 +/- 2.6 Hz, respectively, and were significantly different (P < .005). CONCLUSIONS: Early active MS lesions with nodular enhancement show R2* decrease but no quantitative susceptibility mapping change, reflecting myelin breakdown; late active lesions with peripheral enhancement show R2* decrease and quantitative susceptibility mapping increase in the lesion center, reflecting further degradation and removal of myelin debris; and early or late chronic nonenhancing lesions show both quantitative susceptibility mapping and R2* increase, reflecting iron accumulation.
基金：
U.S. Department of Health and Human Services National Institutes of Health National Institute of Neurological Disorders and Stroke [NS090464]; U.S. Department of Health and Human Services National Institutes of Health National Institute of Biomedical Imaging and Bioengineering [EB134432]; National Natural Science Foundation of China [81401390]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|2 区核医学3 区临床神经病学3 区神经成像
最新[2025]版：
大类|2 区医学
小类|2 区核医学3 区临床神经病学3 区神经成像
JCR分区：
出版当年[2014]版：
Q1CLINICAL NEUROLOGYQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROIMAGING
最新[2023]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2CLINICAL NEUROLOGYQ2NEUROIMAGING
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan, Peoples R China[2]Weill Cornell Med Coll, Dept Radiol, 515 East 71th St, New York, NY 10021 USA
通讯作者：
通讯机构：[2]Weill Cornell Med Coll, Dept Radiol, 515 East 71th St, New York, NY 10021 USA[6]Cornell Univ, Dept Biomed Engn, Ithaca, NY USA
推荐引用方式(GB/T 7714)：
Zhang Y.,Gauthier S. A.,Gupta A.,et al.Quantitative Susceptibility Mapping and R2*Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation[J].AMERICAN JOURNAL OF NEURORADIOLOGY.2016,37(9):1629-1635.doi:10.3174/ajnr.A4825.
APA：
Zhang, Y.,Gauthier, S. A.,Gupta, A.,Chen, W.,Comunale, J....&Wang, Y..(2016).Quantitative Susceptibility Mapping and R2*Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation.AMERICAN JOURNAL OF NEURORADIOLOGY,37,(9)
MLA：
Zhang, Y.,et al."Quantitative Susceptibility Mapping and R2*Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation".AMERICAN JOURNAL OF NEURORADIOLOGY 37..9(2016):1629-1635
