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Low Shear Stress Inhibited Endothelial Cell Autophagy Through TET2 Downregulation

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收录情况： ◇ SCIE ◇ EI

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单位： [1]Univ South China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China [2]Xiang Nan Univ, Affiliated Hosp, Chengzhou 423000, Peoples R China [3]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Neurosurg,Wuhan 430030,Peoples R China [4]Univ South China, Sch Med, Dept Physiol, Hengyang 421001, Peoples R China [5]Univ South China, Sch Med, Inst Neurosci, Hengyang 421001, Peoples R China

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关键词： Low shear stress Autophagy Ten-eleven translocation 2 protein Endothelial cell Atherosclerosis

摘要：

Low shear stress plays a crucial role in the initiation and progression of atherosclerotic lesions. However, the detailed mechanisms of these processes remain unclear. In this study, the effect of low shear stress on endothelial cell autophagy and its potential mechanism were investigated. Results showed autophagy dysfunction and ten-eleven translocation 2 (TET2) protein downregulation during atherosclerotic lesion progression. Autophagic markers BECLIN 1 and LC3II/LC3I under low shear stress (5 dyne/cm(2)) obviously decreased compared with those under physiological shear stress (15 dyne/cm(2)), whereas autophagic substrate p62 increased. TET2 expression was also downregulated under low shear stress. Endothelial cell autophagy was improved with TET2 overexpression but was impaired by TET2 siRNA treatment. Moreover, TET2 overexpression upregulated the expression of endothelial cell nitric oxide synthase (eNOS) and downregulated the expression of endothelin-1 (ET-1). TET2 siRNA further attenuated eNOS expression and stimulated ET-1 expression. Overall, the results showed that low shear stress downregulated endothelial cell autophagy by impaired TET2 expression, which might contribute to the atherogenic process.

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出版当年[2015]版：

大类 | 2 区工程技术

小类 | 2 区工程：生物医学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区工程：生物医学

JCR分区：

出版当年[2014]版：

Q1 ENGINEERING, BIOMEDICAL

最新[2023]版：

Q3 ENGINEERING, BIOMEDICAL

影响因子： 3 最新[2023版] 3.2 最新五年平均 3.195 出版当年[2014版] 2.987 出版当年五年平均 3.231 出版前一年[2013版] 2.887 出版后一年[2015版]

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第一作者单位： [1]Univ South China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Peoples R China

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