Residual renal function (RRF) is an important prognostic factor for peritoneal dialysis patients as it influences the quality of life and mortality. This study was conducted to explore the potential factors correlated with RRF. A cross-sectional study was conducted by recruiting 155 patients with residual GFR more than 1 mL/min per 1.73m(2) at the initiation of peritoneal dialysis. We collected the demographic characteristics, nutritional markers and biochemical parameters of all participants, and analyzed the correlation between these variables and residual GFR as well. The odds ratio of RRF loss associated with each of the nutritional markers and biochemical parameters were estimated by logistic regression model. The residual GFR was negatively correlated with serum phosphate (ORQ3 = 2.67, 95% CI: 1.03-6.92; ORQ4 = 3.45, 95% CI: 1.35-9.04), magnesium (ORQ4 = 3.77, 95% CI: 1.48-3.63), and creatinine (ORQ3 = 2.93, 95% CI: 1.09-7.88; ORQ4 = 8.64 95% CI: 2.792-6.78), while positively associated with normalized protein catabolic rate (ORQ3 = 0.24, 95% CI: 0.09-0.65; ORQ4 = 0.11, 95% CI: 0.03-0.35), 24 hours urine volume(ORQ1 = 22.87, 95% CI: 2.76-189.24; ORQ3 = 0.08, 95% CI: 0.02-0.28) and serum chlorine concentrations (ORQ1 = 5.34, 95% CI: 1.94-14.68; ORQ4 = 0.28, 95% CI: 0.09-0.85), respectively. Our study suggested that the nutritional markers and biochemical parameters, though not all, but at least in part were closely correlated with RRF in peritoneal dialysis patients.
基金:
provincial Science Foundation of Hubei [WJ2015MB011]; National Science Foundation of China (NSF) [81300592]
第一作者单位:[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Clin Nutr, Wuhan 430074, Peoples R China
通讯作者:
通讯机构:[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Clin Nutr, Wuhan 430074, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Nephrol, Wuhan 430074, Peoples R China
推荐引用方式(GB/T 7714):
Li Li,Liang Wangqun,Ye Ting,et al.The Association between Nutritional Markers and Biochemical Parameters and Residual Renal Function in Peritoneal Dialysis Patients[J].PLOS ONE.2016,11(6):doi:10.1371/journal.pone.0156423.
APA:
Li, Li,Liang, Wangqun,Ye, Ting,Chen, Zhenyan,Zuo, Xuezhi...&Yao, Ying.(2016).The Association between Nutritional Markers and Biochemical Parameters and Residual Renal Function in Peritoneal Dialysis Patients.PLOS ONE,11,(6)
MLA:
Li, Li,et al."The Association between Nutritional Markers and Biochemical Parameters and Residual Renal Function in Peritoneal Dialysis Patients".PLOS ONE 11..6(2016)