Two water-stable three-dimensional Mn- and Gd-based metal-organic frameworks (MOFs), -{[Mn-2(Cmdcp)(2)(H2O)(2)]center dot H2O}(n), (1) and {[Gd(Cmdcp)(H2O)(3)](NO3)center dot 3H(2)O}(n) (2, H(3)CmdcpBr = N-(4-carboxy benzyl)-(3,5-dicarboxyl)pyridinium bromide), have been prepared and analyzed. In vitro magnetic resonance imaging indicated that MOFs 1 and 2 possess relaxivity r(1) values of 17.50 and 13.46 m.M-1.S-1, respectively, which are superior to that of the control Gd-DTPA (r(1) = 4.87 mM(-1).S-1, DTPA = diethylene triamine pentaacetate). MOFs 1 and 2 also possessed good biocompatibility and low cytotoxicity against a model cell line. In vivo magnetic resonance images of treated Kunming mice indicated that kidneys showed remarkably positive signal enhancement after 15 min with intravenous administration of MOFs 1 and the hyperintensity of both kidneys persisted for about 240 min with no obvious tissue damage. MOF 1 is therefore promising in vivo probes for imaging intravascular diseases and renal dysfunction.
基金：
National Natural Science Foundation of China [21102070, 81471637]; Natural Science Foundation of Guangdong [2015A030313284]; Guangdong Provincial Natural Science Foundation of China [2015A030313284]; Guangdong Provincial Department of Science and Technology of China [2015A010105016]; Office of Science (BER); Program for Pearl River New Stars of Science and Technology in Guangzhou [2011J2200071]; U.S. Department of Energy [DE-SC0008397]; Southern Medical University
第一作者单位：[1]Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China[2]Southern Med Univ, Sch Pharmaceut Sci, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangzhou 510515, Guangdong, Peoples R China[4]Zhaoqing Univ, Sch Chem & Chem Engn, Zhaoqing 526061, Peoples R China
通讯作者：
通讯机构：[1]Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China[2]Southern Med Univ, Sch Pharmaceut Sci, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangzhou 510515, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Qin Liang,Sun Zi-Yan,Cheng Kai,et al.Zwitterionic Manganese and Gadolinium Metal-Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging[J].ACS APPLIED MATERIALS & INTERFACES.2017,9(47):41378-41386.doi:10.1021/acsami.7b09608.
APA：
Qin, Liang,Sun, Zi-Yan,Cheng, Kai,Liu, Shu-Wen,Pang, Jian-Xin...&Chen, Jin-Xiang.(2017).Zwitterionic Manganese and Gadolinium Metal-Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging.ACS APPLIED MATERIALS & INTERFACES,9,(47)
MLA：
Qin, Liang,et al."Zwitterionic Manganese and Gadolinium Metal-Organic Frameworks as Efficient Contrast Agents for in Vivo Magnetic Resonance Imaging".ACS APPLIED MATERIALS & INTERFACES 9..47(2017):41378-41386
工程技术