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High intraocular pressure produces learning and memory impairments in rats

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Ophthalmol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Dept Neurobiol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China [3]Minist Educ, Key Lab Neurol Dis, Wuhan 430030, Hubei, Peoples R China [4]Gladstone Inst, San Francisco, CA 94158 USA

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关键词： Intraocular pressure Hippocampus Amyloid beta Tau Learning and memory

摘要：

Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocampal changes in a rat model. We used behavioural tests to assess learning and memory ability, and additionally investigated the hippocampal expression of pathological amyloid beta (A beta), phospho-tau, and related pathway proteins. Chronic high IOP impaired learning and memory in rats and concurrently increased A beta and phospho-tau expression in the hippocampus by altering the activation of different kinase (GSK-3 beta, BACE1) and phosphatase (PP2A) proteins in the hippocampus. This study provides novel evidence for the relationship between high IOP and hippocampal alterations, especially in the context of learning and memory. (C) 2017 Elsevier B.V. All rights reserved.

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基金编号： 81471744 81300760 2015TS142

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出版当年[2016]版：

大类 | 3 区医学

小类 | 4 区神经科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区神经科学

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出版当年[2015]版：

Q3 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 2.9 最新五年平均 2.561 出版当年[2015版] 2.856 出版当年五年平均 2.843 出版前一年[2014版] 2.746 出版后一年[2016版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Ophthalmol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

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