In this work, a potent photosensitizer, sinoporphyrin sodium (DVDMS), was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal (PTT/PDT) co-therapy. The resulting nanocomposite formed a well-defined nanocage with a photosensitizer loading capacity as high as 66.67 wt%, which far exceeds those reported previously. The bioengineered protein nanocage-based nanotheranostics exhibits a remarkably improved tumor treatment effect over DVDMS with good biocompatibility and the potential of clinical translation.
基金：
Major State Basic Research Development Program of China [2017YFA0205201, 2013CB733802, 2014CB744503]; National Natural Science Foundation of China (NSFC) [81422023, 51273165, U1505221]; Fundamental Research Funds for the Central Universities [20720160065, 20720150141]; Science Foundation of Fujian Province [2014Y2004]; Program for New Century Excellent Talents in University, China [NCET-13-0502]; Chinese University of Hong Kong Direct Grant for Research [4054167]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Hubei, Peoples R China[2]Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China[3]Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China
通讯作者：
通讯机构：[2]Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China[3]Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China
推荐引用方式(GB/T 7714)：
Huang Chao,Chu Chengchao,Wang Xiaoyong,et al.Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy[J].BIOMATERIALS SCIENCE.2017,5(8):1512-1516.doi:10.1039/c7bm00302a.
APA：
Huang, Chao,Chu, Chengchao,Wang, Xiaoyong,Lin, Huirong,Wang, Junqing...&Liu, Gang.(2017).Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy.BIOMATERIALS SCIENCE,5,(8)
MLA：
Huang, Chao,et al."Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy".BIOMATERIALS SCIENCE 5..8(2017):1512-1516
