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Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway

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收录情况： ◇ SCIE ◇ EI

作者：
Jin, Xun[1,2] * ; Ma, Jingwei[3,4] ; Liang, Xiaoyu[1,2] ; Tang, Ke[3] ; Liu, Yuying[1,2] ; Yin, Xiaonan[1,2] ; Zhang, Yi[1,2] ; Zhang, Huafeng[1,2] ; Xu, Pingwei[3] ; Chen, Degao[1,2] ; Zhang, Tianzhen[1,2] ; Lu, Jinzhi[1,2] ; Hu, Zhuowei[5,6] ; Qin, Xiaofeng[7] ; Zeng, Xiaoyong[8] ; Li, Longcheng[9] ; Huang, Bo[1,2,3] ;
单位： [1]Chinese Acad Med Sci, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China [2]Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing 100005, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Biochem & Mol Biol, Wuhan 430030, Peoples R China [4]Huazhong Univ Sci & Technol, Dept Immunol, Tongji Med Coll, Wuhan 430030, Peoples R China [5]Chinese Acad Med Sci, Inst Mat Med, Mol Immunol & Pharmacol Grp, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China [6]Peking Union Med Coll, Beijing, Peoples R China [7]Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China [8]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Surg, Wuhan 430030, Peoples R China [9]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Mol Med Lab, Beijing 100730, Peoples R China
出处：
DOI： 10.1016/j.biomaterials.2016.10.036
ISSN：

关键词： Bladder cancer cell Microparticles Lysosomes Chemosensitizer Recurrence

摘要：
Nonmuscle-invasive bladder cancer (NMIBC) is treated with transurethral resection followed by intravesical chemotherapy. However, drug-resistant tumorigenic cells cannot be eliminated, leading to half of the treated cancers recur with increased stage and grade. Innovative approaches to enhance drug sensitivity and eradicate tumorigenic cells in NMIBC treatment are urgently needed. Here, we show that pre-instillation of tumor cell-derived microparticles (T-MP) as natural biomaterials markedly enhance the inhibitory effects of intravesical chemotherapy on growth and hematuria occurrence of orthotropic bladder cancer in mice. We provide evidence that T-MPs enter and increase the pH value of lysosomes from 4.6 to 5.6, leading to the migration of drug-loaded lysosomes along microtubule tracks toward the nucleus and discharging the drugs whereby for the entry of the nucleus. We propose that T-MPs may function as a potent sensitizer for augmenting NMIBC chemotherapy with unprecedented clinical benefits. (C) 2016 Elsevier Ltd. All rights reserved.

基金：
National Basic Research Program of China [2014CB542100]; National Science Fund for Distinguished Young Scholars of China [81225021]; National Natural Science Foundation of China [81472653, 81502470]
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类 | 1 区 工程技术
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2015]版：
Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 ENGINEERING, BIOMEDICAL
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者：
第一作者单位： [1]Chinese Acad Med Sci, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China [2]Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing 100005, Peoples R China
通讯作者：
通讯机构： [1]Chinese Acad Med Sci, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China [2]Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing 100005, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Biochem & Mol Biol, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Jin Xun,Ma Jingwei,Liang Xiaoyu,et al.Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway[J].BIOMATERIALS.2017,113:93-104.doi:10.1016/j.biomaterials.2016.10.036.
APA：
Jin, Xun,Ma, Jingwei,Liang, Xiaoyu,Tang, Ke,Liu, Yuying...&Huang, Bo.(2017).Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway.BIOMATERIALS,113,
MLA：
Jin, Xun,et al."Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway".BIOMATERIALS 113.(2017):93-104

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