1α,25-Dihydroxyvitamin D3 inhibits aflatoxin B1-induced proliferation and dedifferentiation of hepatic progenitor cells by regulating PI3K/Akt and Hippo pathways
Hepatic progenitor cells (HPCs) might be the origin of hepatocellular carcinoma.1 alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D-3) (VD3) has been documented as an anticancer agent for various cancers. However, the potential effect of VD3 on the proliferation and malignant transformation of HPCs induced by aflatoxin B1 (AFB1) has not been determined. In this study, we found that AFB1 exhibited the stimulative effects on the proliferation, dedifferentiation and invasion of HPCs via activating AKT pathway but turning off Hippo pathway, which were terminated when VD3 was used in combination with AFB1. Furthermore, in AFB1-induced liver damage mouse model, VD3 also showed protective effect by reducing HPCs population. Together, these preclinical data not only provide a newly identified mechanism by which AFB1 affects HPCs but also strengthen the idea of developing VD3 as an anticancer agent.
基金：
National Natural Science Foundation of China [81300523, 81201554]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Jian,Chen Yan,Mo Ping-Li,et al.1α,25-Dihydroxyvitamin D3 inhibits aflatoxin B1-induced proliferation and dedifferentiation of hepatic progenitor cells by regulating PI3K/Akt and Hippo pathways[J].JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY.2018,183:228-237.doi:10.1016/j.jsbmb.2018.08.002.
APA：
Wang, Jian,Chen, Yan,Mo, Ping-Li,Wei, Yi-Ju,Liu, Kuan-Cheng...&Zhang, Lei.(2018).1α,25-Dihydroxyvitamin D3 inhibits aflatoxin B1-induced proliferation and dedifferentiation of hepatic progenitor cells by regulating PI3K/Akt and Hippo pathways.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,183,
MLA：
Wang, Jian,et al."1α,25-Dihydroxyvitamin D3 inhibits aflatoxin B1-induced proliferation and dedifferentiation of hepatic progenitor cells by regulating PI3K/Akt and Hippo pathways".JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 183.(2018):228-237
