Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution. Additionally, WMO-II reduced the number of apoptotic bodies in stored kidneys compared to HTK treated tissue after 48 h of cold storage by reducing expression of Caspase-9, BiP, Chop, and Caspase-12. WMO-II solution reduced serum creatinine levels and serum potassium in kidneys stored for 48 h when compared to HTK perfusion. WMO-II preserves kidney function as evidenced by the reduction in serum creatinine and potassium during graft transplantation.
基金：
National Natural Science Foundation of China [81570678]; Clinical Research Physician Program of Tongji Medical College, HUST; Major State Basic Research Development Program of China [2013CB530803]; National High-Tech Research and Development Program (Program 863) of the Ministry of Science and Technology of China [2012AA021010]; Translational Grant of Tongji Hospital
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Inst Organ Transplantat,Key Lab,Minist Hlth,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Minist Educ,Wuhan 430030,Hubei,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Inst Organ Transplantat,Key Lab,Minist Hlth,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Minist Educ,Wuhan 430030,Hubei,Peoples R China
推荐引用方式(GB/T 7714)：
Wang Sheng,Gumpper Kristyn,Tan Tao,et al.A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model[J].CELL AND BIOSCIENCE.2018,8:doi:10.1186/s13578-018-0226-2.
APA：
Wang, Sheng,Gumpper, Kristyn,Tan, Tao,Luo, Xianzhang,Guo, Hui...&Gong, Nianqiao.(2018).A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model.CELL AND BIOSCIENCE,8,
MLA：
Wang, Sheng,et al."A novel organ preservation solution with efficient clearance of red blood cells improves kidney transplantation in a canine model".CELL AND BIOSCIENCE 8.(2018)
生物学