Objective The aim of the present study was to comprehensively compare noninvasive and invasive blood pressure (BP) measured by the Philips Intellivue MP50 monitor in surgeries that may induce gall cardiac reflex under general anesthesia. Participants and methods Seventy-eight patients undergoing cholecyst or bile duct operations under general anesthesia were enrolled in our study. Both invasive (intraradial, femoral, or dorsalis pedis artery) and noninvasive (oscillometric) BP were monitored by the Philips Intellivue MP50 monitor simultaneously. Data were analyzed using Bland-Altman plots. Results In a supine position during operations, between intraradial and oscillometric measurements, the bias and precision (mmHg) were 9.34 +/- 12.98 and 12.47 +/- 10.00 for systolic blood pressure (SBP) and 3.26 +/- 8.22 and 6.53 +/- 5.97 for diastolic blood pressure (DBP), between intrafemoral and oscillometric measurements, the bias and precision (mmHg) were 14.40 +/- 14.38 and 16.93 +/- 11.28 for SBP and 4.35 +/- 9.72 and 7.52 +/- 7.54 for DBP, between intradorsalis pedis and oscillometric measurements, the bias and precision (mmHg) were 15.69 +/- 14.37 and 16.91 +/- 12.91 for SBP and 0.99 +/- 7.69 and 5.67 +/- 5.27 for DBP. Conclusion The oscillometric BP showed poor agreement with intra-arterial BP in cholecyst or bile duct surgeries that may induce gall cardiac reflex under general anesthesia. Therefore, according to the present data, application of oscillometric BP measured by the Philips Intellivue MP50 monitor in these surgery patients under general anesthesia cannot be recommended generally. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.