单位：[1]Anesthesiology Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院麻醉学研究所麻醉科[2]Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院麻醉科[3]Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院肿瘤科[4]Department of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany[5]Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[6]Department of Oncology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, China
Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species (ROS) in inflammatory and neuropathic pain, and ROS scavengers exhibited potent antinociceptive effect. However, the role of spinal ROS remains unclear. In this study, we investigated the analgesic effect of two ROS scavengers in a well-established CIBP model. Our results found that intraperitoneal injection of N-tert-Butyl-alpha-phenylnitrone (PBN, 50 and 100 mg/kg) and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol, 100 and 200 mg/kg) significantly suppressed the established mechanical allodynia in CIBP rats. Moreover, repeated injection of PBN and Tempol showed cumulative analgesic effect without tolerance. However, early treatment with PBN and Tempol failed to prevent the development of CIBP. Naive rats received repetitive injection of PBN and Tempol showed no significant change regarding the nociceptive responses. Finally, PBN and Tempol treatment notably suppressed the activation of spinal microglia in CIBP rats. In conclusion, ROS scavengers attenuated established CIBP by suppressing the activation of microglia in the spinal cord.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81400917, 81371250, 81571053]
第一作者单位：[1]Anesthesiology Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China[2]Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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推荐引用方式(GB/T 7714)：
Zhou Ya-Qun,Liu Dai-Qiang,Chen Shu-Ping,et al.Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain[J].REDOX BIOLOGY.2018,14:391-397.doi:10.1016/j.redox.2017.10.011.
APA：
Zhou, Ya-Qun,Liu, Dai-Qiang,Chen, Shu-Ping,Sun, Jia,Zhou, Xue-Rong...&Ye, Da-Wei.(2018).Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain.REDOX BIOLOGY,14,
MLA：
Zhou, Ya-Qun,et al."Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain".REDOX BIOLOGY 14.(2018):391-397
生物学