Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, and it's rare for them to originate from the duodenum. Our report illustrates a 63-year-old woman who underwent pancreaticoduodenectomy (PD) due to a duodenal GIST 13 years ago. After that, the patient experienced unresectable multifocal hepatic metastases. As treatments of sunitinib malate, imatinib mesylate and transarterial chemoembolization (TACE) proved ineffective, she underwent a liver transplantation and finally recovered. Histopathology proved the tumor to be a case of a metastatic GIST. The 12-month follow-up after the transplantation showed that the patient is tumor-free under treatment with immunosuppressant and Stivarga. To the best of our knowledge, this is the only case report published in the English medical literature on an elderly patient with metastasized hepatic GIST after PD due to a duodenal GIST with a 13-year remission, who underwent a liver transplantation successfully. Liver transplantation might be an alternative option with a better prognosis for highly selected patients with unresectable metastatic GIST to the liver.