单位：[1]Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China[2]Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China[3]Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China[4]the Peking Union Medical College Hospital[5]the First Affiliated Hospital of Xinjiang Medical University[6]West China Hospital, Sichuan University四川大学华西医院[7]the Children’s Hospital of Fudan University[8]the First Affiliated Hospital of Anhui Medical University[9]Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology华中科技大学同济医学院附属同济医院[10]Ruijin Hospital, Shanghai Jiaotong University School of Medcine[11]the First Affiliated Hospital of China Medical University[12]Tianjin Medical University General Hospital[13]Sir Run Run Shaw Hospital, Zhejiang University School of Medicine[14]the First Affiliated Hospital of Kunming Medical University昆明医科大学附属第一医院[15]the First Affiliated Hospital of Inner Mongolia Medical University[16]the Gansu Provincial Hospital[17]the Children’s Hospital of Shanghai[18]Beijing Hospital[19]the First Affiliated Hospital of Guangzhou Medical University[20]the Pudong New Area People’s Hospital[21]the Zhejiang Ningbo Zhenhai Longsai Hospital[22]the People’s Hospital of Zigui, Hubei Province[23]the First Affiliated Hospital of Harbin Medical University[24]Xiangya Hospital, Central South University[25]Shandong Provincial Hospital[26]the Jinjiang Municipal Hospital[27]the China-Japan Union Hospital, Jilin University吉林大学中日联谊医院[28]the Sichuan Provincial People’s Hospital四川省人民医院[29]the Henan Provincial People’s Hospital[30]the Shaanxi Provincial People’s Hospital[31]the Jiangxi Provincial Children’s Hospital[32]the Children’s Hospital of Shanxi[33]the Beijing Children’s Hospital, Capital Medical University首都医科大学附属北京儿童医院[34]the Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing[35]the General Hospital of Ningxia Medical University[36]the Shenzhen People’s Hospital深圳市人民医院深圳医学信息中心[37]the Second Hospital of Hebei Medical University[38]Jinchang Hospital of integrated traditional Chinese and Western Medicine[39]The People’s Hospital of Ganxian[40]Guangrao County People's Hospital[41]The People’s Hospital of Huixian, Henan Province[42]Central Hospital of Yingkou Development Zone, Liaoning Province[43]Huzhu County People's Hospital, Qinghai Province[44]The People’s Hospital of Linshui, Sichuan Province[45]Lixin County People's Hospital[46]Jiutai People's Hospital.
The aim of this study is to investigate the antimicrobial susceptibility of strains isolated from the major hospitals in China. A total of 44 teaching hospitals were involved. Antimicrobial susceptibility testing was conducted by Kirby-Bauer automated systems, and results were interpreted using CLSI criteria. Totally 244,843 strains were isolated in 2018, of which gram-negative bacilli and gram-positive cocci were accounting for 71.8% and 28.2%, respectively. 39.7% of isolates were cultured from lower respiratory tract, 18.8% from urine, 14.8% from blood, 1.3% from cerebrospinal fluid, respectively. Of those, the five major species were most often isolated (65.5%, 63%, 52.3%, and 30.3%). The resistance rate of MRSA to most antimicrobial agents was significantly higher than that of MSSA strains, except for to trimethoprim-sulfamethoxazole in urine specimen. E.coli was still highly susceptible to carbapenem antibiotics, and the resistance rate was less than 5%. Carbapenem resistance among Klebsiella pneumoniae, especially cultured from cerebrospinal fluid, increased significance from 18.6 to 64.1%. The resistance rates of Pseudomonas aeruginosa to carbapenems were nearly 30% in the blood, in urine, and in the lower respiratory tract, but about 60% of that in cerebrospinal fluid. About 80% of Acinetobacter baumannii strains was resistant to imipenem and meropenem, respectively. Bacterial resistance of five major clinical isolates from cerebrospinal fluid to common antibiotics (in particular Carbapenem-resistant Klebsiella pneumoniae) currently shows an increasing trend. It is worth to emphasize the importance of serious control of hospital infection and better management of clinical use of antimicrobial agents.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81871690]; Pfizer Investigator Initiated Research [WI 207259]
第一作者单位：[1]Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China[2]Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China
推荐引用方式(GB/T 7714)：
Fupin Hu,Yan Guo,Yang Yang,et al.Resistance reported from China antimicrobial surveillance network (CHINET) in 2018[J].EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES.2019,38(12):2275-2281.doi:10.1007/s10096-019-03673-1.
APA：
Fupin Hu,Yan Guo,Yang Yang,Yonggui Zheng,Shi Wu...&the China Antimicrobial Surveillance Network.(2019).Resistance reported from China antimicrobial surveillance network (CHINET) in 2018.EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,38,(12)
MLA：
Fupin Hu,et al."Resistance reported from China antimicrobial surveillance network (CHINET) in 2018".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 38..12(2019):2275-2281
