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Comparative liver function models for ruptured hepatocellular carcinoma: A 10-year single center experience

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单位: [1]Huazhong Univ Sci & Technol,Dept Hepat Surg Ctr,Tongji Hosp,Tongji Med Coll,1095 Jiefang Ave,Wuhan,Hubei,Peoples R China [2]Huazhong Univ Sci & Technol,Dept Neurol Ctr,Tongji Hosp,Tongji Med Coll,Wuhan,Hubei,Peoples R China
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关键词: Albumin Bilirubin Survival Rupture Liver function Model

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Background/Objective: Previous studies have proposed several objective means for liver function assessment in hepatocellular carcinoma (HCC) patients; however, their efficiency in predicting survival of HCC rupture is unknown. Our study aims to confirm which is a better liver function model for ruptured HCC. Methods: A total of 230 patients with HCC ruptures at our center were included. Kaplan-Meier and Cox regression analyses were performed to compare long-term survival and short-term mortality. The 90-day mortality was compared with the area under the receiver characteristic curve. Logistic regression was used to determine the risk factors for 90-day deaths, and the discriminant ability of the model was measured. Results: There were significant differences in predicting OS of the Child-Pugh (CP) score in all patients, the non-surgical subgroup, and the surgical subgroup (all P < 0.0001). But no statistical significance was shown of the ALBI score in the surgical (P = 0.8985) or non-surgical subgroup (P = 0.0634). The CP score yielded a better performance among all patients (AUC = 0.746 vs. 0.712), the surgical subgroup (AUC = 0.558 vs. 0.530), and the non-surgical subgroup (AUC = 0.715 vs. 0.634) compared to ALBI score in predicting ninety-day mortality. A similar result can be found in the subgroup of surgical and non-surgical treatment group. Moreover, the logistic model that included CP or MELD had a better discriminatory ability than ALBI in predicting ninety-day mortality. Conclusion: The CP or MELD rather than ALBI score should be used as a liver function classification criterion for HCC rupture. (C) 2019 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 4 区 外科
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 外科
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Q2 SURGERY
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Q1 SURGERY

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第一作者单位: [1]Huazhong Univ Sci & Technol,Dept Hepat Surg Ctr,Tongji Hosp,Tongji Med Coll,1095 Jiefang Ave,Wuhan,Hubei,Peoples R China
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