Background/Objective: Previous studies have proposed several objective means for liver function assessment in hepatocellular carcinoma (HCC) patients; however, their efficiency in predicting survival of HCC rupture is unknown. Our study aims to confirm which is a better liver function model for ruptured HCC. Methods: A total of 230 patients with HCC ruptures at our center were included. Kaplan-Meier and Cox regression analyses were performed to compare long-term survival and short-term mortality. The 90-day mortality was compared with the area under the receiver characteristic curve. Logistic regression was used to determine the risk factors for 90-day deaths, and the discriminant ability of the model was measured. Results: There were significant differences in predicting OS of the Child-Pugh (CP) score in all patients, the non-surgical subgroup, and the surgical subgroup (all P < 0.0001). But no statistical significance was shown of the ALBI score in the surgical (P = 0.8985) or non-surgical subgroup (P = 0.0634). The CP score yielded a better performance among all patients (AUC = 0.746 vs. 0.712), the surgical subgroup (AUC = 0.558 vs. 0.530), and the non-surgical subgroup (AUC = 0.715 vs. 0.634) compared to ALBI score in predicting ninety-day mortality. A similar result can be found in the subgroup of surgical and non-surgical treatment group. Moreover, the logistic model that included CP or MELD had a better discriminatory ability than ALBI in predicting ninety-day mortality. Conclusion: The CP or MELD rather than ALBI score should be used as a liver function classification criterion for HCC rupture. (C) 2019 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V.
基金:
National Natural Science Foundation of China [81502530]
第一作者单位:[1]Huazhong Univ Sci & Technol,Dept Hepat Surg Ctr,Tongji Hosp,Tongji Med Coll,1095 Jiefang Ave,Wuhan,Hubei,Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Wu Jing-jing,Zhang Zhan-guo,Zhu Peng,et al.Comparative liver function models for ruptured hepatocellular carcinoma: A 10-year single center experience[J].ASIAN JOURNAL OF SURGERY.2019,42(9):874-882.doi:10.1016/j.asjsur.2018.12.015.
APA:
Wu, Jing-jing,Zhang, Zhan-guo,Zhu, Peng,Mba'nbo-koumpa, Abdoul-aziz,Zhang, Bi-xiang...&Li, Gan-xun.(2019).Comparative liver function models for ruptured hepatocellular carcinoma: A 10-year single center experience.ASIAN JOURNAL OF SURGERY,42,(9)
MLA:
Wu, Jing-jing,et al."Comparative liver function models for ruptured hepatocellular carcinoma: A 10-year single center experience".ASIAN JOURNAL OF SURGERY 42..9(2019):874-882