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Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection

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收录情况： ◇ SCIE

作者：
takeuchi,fumihiko[1] * ; kukimoto,iwao[2] * ; li,zhiqiang[3,4,5,6,7] * ; li,shuang[8] * ; li,ni[9,10] * ; hu,zhibin[11,12] * ; takahashi,atsushi[13,14] * ; inoue,shusaku[15] * ; yokoi,sana[16,17] * ; chen,jianhua[5,6,18] ; hang,dong[11] ; kuroda,makoto[19] ; matsuda,fumihiko[20] ; mizuno,mika[21] ; mori,seiichiro[2] ; wu,peng[8] ; tanaka,naotake[22] * ; matsuo,keitaro[15,23] * ; kamatani,yoichiro[13,20] * ; kubo,michiaki[24] * ; ma,ding[8] * ; shi,yongyong[3,4,5,6,7,18,*1] * ;
单位： [1]Natl Ctr Global Hlth & Med, Res Inst, Tokyo 1628655, Japan [2]Natl Inst Infect Dis, Pathogen Genom Ctr, Musashimurayama, Tokyo, Japan [3]Qingdao Univ, Affiliated Hosp, Qingdao, Peoples R China [4]Qingdao Univ, Biomed Sci Inst, Qingdao Branch, SJTU Bio X Inst, Qingdao, Peoples R China [5]Shanghai Jiao Tong Univ, Collaborat Innovat Ctr Brain Sci, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst,Minist Educ, Shanghai, Peoples R China [6]Shanghai Jiao Tong Univ, Inst Social Cognit & Behav Sci, Shanghai, Peoples R China [7]Shanghai Jiao Tong Univ, Inst Neuropsychiat Sci & Syst Biol Med, Shanghai, Peoples R China [8]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan 430030, Hubei, Peoples R China [9]Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Program Off Canc Screening Urban China, Beijing, Peoples R China [10]Peking Union Med Coll, Beijing, Peoples R China [11]Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Sch Publ Hlth,Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China [12]Nanjing Med Univ, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China [13]RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan [14]Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Genom Med, Osaka, Japan [15]Aichi Canc Ctr, Res Inst, Div Mol & Clin Epidemiol, Nagoya, Aichi, Japan [16]Chiba Canc Ctr, Res Inst, Canc Genome Ctr, Chiba, Japan [17]Chiba Canc Ctr, Div Genet Diagnost, Chiba, Japan [18]Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China [19]Natl Inst Infect Dis, Pathogen Genom Ctr, Shinjuku Ku, Tokyo, Japan [20]Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto, Japan [21]Aichi Canc Ctr Hosp, Dept Gynecol Oncol, Nagoya, Aichi, Japan [22]Chiba Canc Ctr, Div Gynecol, Chiba, Japan [23]Nagoya Univ, Grad Sch Med, Dept Epidemiol, Nagoya, Aichi, Japan [24]RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
出处：
DOI： 10.1093/hmg/ddy390
ISSN：

摘要：
The development of cervical cancer is initiated by human papillomavirus (HPV) infection and involves both viral and host genetic factors. Genome-wide association studies (GWAS) of cervical cancer have identified associations in the HLA locus and two loci outside HLA, but the principal genes that control infection and pathogenesis have not been identified. In the present study, we performed GWAS of cervical cancer in East Asian populations, involving 2609 cases and 4712 controls in the discovery stage and 1461 cases and 3295 controls in the follow-up stage. We identified novel-significant associations at 5q14 with the lead single nucleotide polymorphism (SNP) rs59661306 (P = 2.4 x 10(-11)) and at 7p11 with the lead SNP rs7457728 (P = 1.2 x 10(-8)). In 5q14, the chromatin region of the GWAS-significant SNPs was found to be in contact with the promoter of the ARRDC3 (arrestin domain-containing 3) gene. In our functional studies, ARRDC3 knockdown in HeLa cells caused significant reductions in both cell growth and susceptibility to HPV16 pseudovirion infection, suggesting that ARRDC3 is involved in the infectious entry of HPV into the cell. Our study advances the understanding of host genes that are responsible for cervical cancer susceptibility and guides future research on HPV infection and cancer development.

基金：
Ministry of Education, Culture, Sports, Sciences and Technology of Japanese governmentMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Agency for Medical Research and Development (BioBank Japan project)Japan Agency for Medical Research and Development (AMED); 973 ProgramNational Basic Research Program of China [2015CB559100]; National Key R&D Program of China [2016YFC0903402]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31325014, 81421061, 81701321, 81501154]; Program of Shanghai Subject Chief Scientist [15XD1502200]; Japan Society for the Promotion of Science KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP25462624, JP15K10740, JP16K07218]

基金编号： 2015CB559100 2016YFC0903402 31325014 81421061 81701321 81501154 15XD1502200 JP25462624 JP15K10740 JP16K07218

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 生物
小类 | 2 区 生化与分子生物学 2 区 遗传学
最新[2025]版：
大类 | 2 区 生物学
小类 | 3 区 生化与分子生物学 3 区 遗传学
JCR分区：
出版当年[2017]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 GENETICS & HEREDITY
最新[2024]版：
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 GENETICS & HEREDITY

影响因子： 最新[2024版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者单位： [1]Natl Ctr Global Hlth & Med, Res Inst, Tokyo 1628655, Japan
共同第一作者：
通讯作者：
通讯机构： [3]Qingdao Univ, Affiliated Hosp, Qingdao, Peoples R China [*1]Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Bio X Inst, Shanghai 200030, Peoples R China
推荐引用方式(GB/T 7714)：
takeuchi fumihiko,kukimoto iwao,li zhiqiang,et al.Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection[J].HUMAN MOLECULAR GENETICS.2019,28(2):341-348.doi:10.1093/hmg/ddy390.
APA：
takeuchi,fumihiko,kukimoto,iwao,li,zhiqiang,li,shuang,li,ni...&shi,yongyong.(2019).Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection.HUMAN MOLECULAR GENETICS,28,(2)
MLA：
takeuchi,fumihiko,et al."Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection".HUMAN MOLECULAR GENETICS 28..2(2019):341-348

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