单位：[1]Department of Laboratory Medicine,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属同济医院检验科[2]Department of Emergency Medicine,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属同济医院急诊医学科[3]Department of Respiratory and Critical Care Medicine,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属同济医院呼吸内科
BACKGROUND. The coronavirus disease 2019 (COVID-19), infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a severe outbreak throughout the world. The host immunity of COVID-19 patients is unknown. METHODS. The routine laboratory tests and host immunity in COVID-19 patients with different severity of illness were compared after patient admission. RESULTS. A total of 65 SARS-CoV-2-positive patients were classified as having mild (n = 30), severe (n = 20), and extremely severe (n = 15) illness. Many routine laboratory tests, such as ferritin, lactate dehydrogenase, and D-dimer, were increased in severe and extremely severe patients. The absolute numbers of CD4(+) T cells, CD8(+) T cells, and B cells were gradually decreased with increased severity of illness. The activation markers such as HLA-DR and CD45RO expressed on CD4(+) and CD8(+) T cells were increased in severe and extremely severe patients compared with mild patients. The costimulatory molecule CD28 had opposite results. The percentage of natural Tregs was decreased in extremely severe patients. The percentage of IFN-gamma-producing CD8(+) T cells was increased in both severe and extremely severe patients compared with mild patients. The percentage of IFN-gamma-producing CD8(+) T cells was increased in extremely severe patients. IL-2R, 1L-6, and IL-10 were all increased in extremely severe patients. The activation of DC and B cells was decreased in extremely severe patients. CONCLUSION. The number and function of T cells are inconsistent in COVID-19 patients. The hyperfunction of CD4(+) and CD8(+) T cells is associated with the pathogenesis of extremely severe SARS-CoV-2 infection.
基金：
National Mega Project on Major Infectious Disease Prevention [2017ZX10103005007]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2019kfyRCPY098]
第一作者单位：[1]Department of Laboratory Medicine,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Laboratory Medicine,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[2]Department of Emergency Medicine,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[3]Department of Respiratory and Critical Care Medicine,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.[*1]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1095, Wuhan 430030, China.
推荐引用方式(GB/T 7714)：
Feng Wang,Hongyan Hou,Ying Luo,et al.The laboratory tests and host immunity of COVID-19 patients with different severity of illness[J].JCI INSIGHT.2020,5(10):doi:10.1172/jci.insight.137799.
APA：
Feng Wang,Hongyan Hou,Ying Luo,Guoxing Tang,Shiji Wu...&Ziyong Sun.(2020).The laboratory tests and host immunity of COVID-19 patients with different severity of illness.JCI INSIGHT,5,(10)
MLA：
Feng Wang,et al."The laboratory tests and host immunity of COVID-19 patients with different severity of illness".JCI INSIGHT 5..10(2020)
医学