单位：[1]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[2]Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China华中科技大学同济医学院附属同济医院胆胰外科外科学系[3] Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[4]Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Pancreatic cancer is one of the most lethal human malignancies, partly because of its propensity for metastasis. However, the mechanisms of metastasis in pancreatic cancer remain unclear. Oxidized low-density lipoprotein receptor 1 (OLR1), a lectin-like scavenger receptor that recognizes several ligands, such as oxidized low-density lipoprotein, was previously reported in cardiovascular and metabolic diseases. The role and mechanism of OLR1 in pancreatic cancer is unclear. In this study, we found that OLR1 expression was significantly higher in pancreatic cancer tissues than that in adjacent normal tissues and closely associated with reduced overall survival. OLR1 promoted proliferation and metastasis of pancreatic cancer cells in vitro and in vivo. Mechanistically, OLR1 increased HMGA2 transcription by upregulating c-Myc expression to promote the metastasis of pancreatic cancer cells. In addition, patients with pancreatic cancer with high expression of OLR1-c-Myc-HMGA2 axis showed worse prognosis compared with patients with low expression of OLR1-c-Myc-HMGA2 axis. Implications: Our findings suggested that the OLR1-c-MycHMGA2 axis promotes metastasis of pancreatic cancer cells and may serve as potential therapeutic targets and prognosis markers for patients with pancreatic cancer.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81974376, 81772639, 81972258]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-001]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2018PT32014, 2018PT32002]; CAMS Innovation Fund for Medical Students [2017-1002-1-16]; PUMC Youth Fund; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2017320027]
第一作者单位：[1]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
通讯作者：
通讯机构：[1]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[4]Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.[*1]Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1# Shuai Fu Yuan Hu Tong, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Yang Gang,Xiong Guangbing,Feng Mengyu,et al.OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2[J].MOLECULAR CANCER RESEARCH.2020,18(5):685-697.doi:10.1158/1541-7786.MCR-19-0718.
APA：
Yang, Gang,Xiong, Guangbing,Feng, Mengyu,Zhao, Fangyu,Qiu, Jiangdong...&Zhao, Yupei.(2020).OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2.MOLECULAR CANCER RESEARCH,18,(5)
MLA：
Yang, Gang,et al."OLR1 Promotes Pancreatic Cancer Metastasis via Increased c-Myc Expression and Transcription of HMGA2".MOLECULAR CANCER RESEARCH 18..5(2020):685-697
