单位:[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan, Peoples R China华中科技大学同济医学院附属协和医院[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Gastrointestinal Surg,Wuhan,Peoples R China华中科技大学同济医学院附属同济医院外科学系胃肠外科[3]Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53706 USA[4]Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol, 1300 Univ Ave, Madison, WI 53706 USA
The larynx is a complex organ which has a role in a variety of functions such as phonation, breathing, and swallowing. To research these functions, it is widely accepted that in vivo studies provide more anatomically and physiologically relevant findings. However, invasive procedures are generally needed to measure variables such a subglottal pressure, vocal fold tension and stiffness, and cricothyroid muscle stretch. Performing studies using excised larynges is a useful technique which makes it possible to not only measure phonation parameters but control them as well. Early studies using excised larynges mainly focused on controlling specific parameters and mathematical modeling simulations. The use of these studies has helped further research in laryngeal anatomy, imaging techniques, as well as aerodynamic, acoustic, and biomechanical properties. Here, we describe the progress of this research over the past 5 years. The number of accepted animal models has increased and ideas from excised larynx studies are starting to be applied to treatment methods for laryngeal disorders. These experiments are only valid for an excised situation and must continue to be combined with animal experimentation and clinical observations.
基金:
National Institute of Health grant NIH/NIDCD [2R01 DC006019]
第一作者单位:[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan, Peoples R China
通讯作者:
通讯机构:[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan, Peoples R China[3]Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI 53706 USA[4]Univ Wisconsin, Sch Med & Publ Hlth, Dept Surg, Div Otolaryngol, 1300 Univ Ave, Madison, WI 53706 USA
推荐引用方式(GB/T 7714):
Luo Rong,Kong Weijia,Wei Xin,et al.Development of Excised Larynx[J].JOURNAL OF VOICE.2020,34(1):38-43.doi:10.1016/j.jvoice.2018.07.023.
APA:
Luo, Rong,Kong, Weijia,Wei, Xin,Lamb, Jim&Jiang, Jack J..(2020).Development of Excised Larynx.JOURNAL OF VOICE,34,(1)
MLA:
Luo, Rong,et al."Development of Excised Larynx".JOURNAL OF VOICE 34..1(2020):38-43