The aim of this article is to study the effect of miR-486-5p in acute lung injury (ALI). MiR-486-5p expression in peripheral blood was determined in ALI patients and healthy volunteers by qRT-PCR. ALI mouse model were reproduced by LPS treatment, and miR-486-5p NC and miRNA-486 inhibitors were injected through trachea. ALI patients' peripheral blood and LPS-induced acute lung injury in mice had significantly higher miR-486-5p levels than control subjects. Inhibition of miR-486-5p by injection with antagomiR-486-5p markedly reduced LPS-induced lung inflammation. Moreover, knockdown of miR-486-5p can reduce protects A549 cell against LPS-induced injury and its corresponding inflammatory response. In addition, Mechanistic analysis indicated that miR-486-5p on the occurrence of ALI is related to the inhibition of OTUD7B activity, which induces the downregulation of inflammatory in ALI. Our results identified miR-486-5p independently associated with ALI. miR-486-5p can mediate the formation of ALI by promoting inflammation.
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Emergency & Traumat Surg, Tongji Med Coll, Trauma Ctr,Tongji Hosp, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Luo Qiang,Zhu Jun,Zhang Qian,et al.MicroRNA-486-5p Promotes Acute Lung Injury via Inducing Inflammation and Apoptosis by Targeting OTUD7B[J].INFLAMMATION.2020,43(3):975-984.doi:10.1007/s10753-020-01183-3.
APA：
Luo, Qiang,Zhu, Jun,Zhang, Qian,Xie, Jie,Yi, Chengla&Li, Tianyu.(2020).MicroRNA-486-5p Promotes Acute Lung Injury via Inducing Inflammation and Apoptosis by Targeting OTUD7B.INFLAMMATION,43,(3)
MLA：
Luo, Qiang,et al."MicroRNA-486-5p Promotes Acute Lung Injury via Inducing Inflammation and Apoptosis by Targeting OTUD7B".INFLAMMATION 43..3(2020):975-984
