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Discrimination of cervical cancer cells via cognition-based features

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单位: [1]Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Sch Engn Sci, MoE Key Lab Biomed Photon, Wuhan 430074, Hubei, Peoples R China [3]Huazhong Univ Sci & Technol, Dept Clin Lab, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China [4]Hubei Maternal & Child Hlth Hosp, Dept Pathol, Wuhan 430072, Hubei, Peoples R China
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关键词: Cervical cancer instance segmentation nucleus classiffication lesion cognition

摘要:
Computer-assisted cervical screening is an effective method to save the doctors' workload and improve their work efficiency. Usually, the correct classification of cervical cells depends on the nuclear segmentation effect and the extraction of nuclear features. However, the precise nucleus segmentation remains a huge challenge, especially for densely distributed nucleus. Moreover, previous cellular classification methods are mostly based on morphological features of nucleus size or color. Those individual features can make accurate classification for severe lesions, but not for mild lesions. In this paper, we propose an accurate instance segmentation algorithm and propose cognition-based features to identify cervical cancer cells. Different from previous individual nucleus features, we also propose population features and cognition-based features according to the Bethesda System (TBS) for reporting cervical cytology and the diagnostic experience of the cytologists. The results showed that the segmentation achieves better success in complex situations than that by traditional segmentation algorithms. Besides, the cell classification via cognition-based features also help us find out more about less severe lesions' nuclei than that based on conventional features of individual nucleus, meaning an improvement of classification accuracy for cervical screening.

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出版当年[2019]版:
大类 | 4 区 医学
小类 | 4 区 光学 4 区 核医学
最新[2025]版:
大类 | 4 区 医学
小类 | 3 区 光学 4 区 核医学
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出版当年[2018]版:
Q4 OPTICS Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q2 OPTICS Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者单位: [1]Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan 430074, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Sch Engn Sci, MoE Key Lab Biomed Photon, Wuhan 430074, Hubei, Peoples R China
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