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Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

作者：
Huang, Fen[1] * ; Xiong, Xiaofang[2] ; Wang, Huabin[2] ; You, Sha[1] ; Zeng, Hesong[1] ;
单位： [1]Huazhong Univ Sci & Technol, Dept Cardiol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China [2]Third Hosp Wuhan, Dept Cardiol, Wuhan 430060, Peoples R China
出处：
DOI： 10.1093/abbs/gmq025
ISSN：

关键词： leptin smooth muscle cell cell cycle ERK1/2 NF-kappa B

摘要：
Leptin is a peptide hormone primarily involved in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is one of the risk factors for cardiovascular diseases including atherosclerosis and hypertension. Vascular smooth muscle cells (VSMCs) play a vital role in arterial intimal thickening and vascular remodeling. In this study, we investigated the effect of leptin on VSMC cell-cycle regulation and the possible pathway. We found that leptin stimulated VSMC proliferation and increased cell progression to S and G2/M phases. The expression of cyclinD1, phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), and nuclear factor (NF)-kappa Bp65 was increased. Treatment of the cells with leptin antagonist triple mutant attenuated the leptin-induced ERK1/2 and NF-kappa B activation. These results suggested that leptin stimulated VSMC proliferation by promoting transition from G1 to S phase and ERK1/2 and NF-kappa B pathway might contribute to this procession.

基金：
National Natural Science Foundation of China [30470713]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类 | 4 区 生物
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 生物物理
JCR分区：
出版当年[2008]版：
Q4 BIOPHYSICS Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2008版] 出版当年五年平均 出版前一年[2007版] 出版后一年[2009版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Dept Cardiol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Huang Fen,Xiong Xiaofang,Wang Huabin,et al.Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB[J].ACTA BIOCHIMICA ET BIOPHYSICA SINICA.2010,42(5):325-331.doi:10.1093/abbs/gmq025.
APA：
Huang, Fen,Xiong, Xiaofang,Wang, Huabin,You, Sha&Zeng, Hesong.(2010).Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,42,(5)
MLA：
Huang, Fen,et al."Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 42..5(2010):325-331

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