单位：[1]Institute of Integrative Traditional and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China华中科技大学同济医学院附属同济医院中西医结合研究所[2]Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China华中科技大学同济医学院附属同济医院放射科
Haemorheological abnormalities have been described in diabetes mellitus,as well as in non-alcoholic fatty liver disease (NAFLD).However,the relationship between the changes in liver fat content and haemorheology is unknown.The current study aims to show the correlation between haemorheological parameters and intrahepatic lipid content (IHLC) in patients with type 2 diabetes.The serum biochemical markers,such as fasting plasma glucose (FPG),haemoglobin A1c (HbA1c),liver enzymes,lipid profiles,and haemorheological properties,were examined.IHLC was quantified using proton magnetic resonance spectroscopy (1H-MRS) scanning of the liver.A significant correlation was observed between IHLC and whole blood viscosity at high,middle,and low shear rates.IHLC also positively correlated with haematocrit,the reduced whole blood viscosity at low and middle shear rates,and the erythrocyte aggregation index.Diabetic patients with NAFLD exhibited significant haemorheological abnormalities compared with patients without NAFLD.In summary,haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.
基金：
The authors thank Dr. Jian-Ping Qi of the Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, for his valuable advice on 1H-MRS methodology. This study was supported by the National Natural Science Foundation of China (Grant No. 30801492).
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大类|2 区医学
小类|2 区医学：内科2 区医学：研究与实验2 区肿瘤学
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推荐引用方式(GB/T 7714)：
Dong H,Lu F,Wang N,et al.Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities[J].Frontiers of Medicine.2011,5(3):288-293.doi:10.1007/s11684-011-0127-9.
APA：
Dong, H,Lu, F,Wang, N,Zou, X&Rao, J.(2011).Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities.Frontiers of Medicine,5,(3)
MLA：
Dong, H,et al."Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities".Frontiers of Medicine 5..3(2011):288-293
