单位：[1]Department of General Surgery, Tongji Hospital of Tongji University, Shanghai 200065, China[2]Central Laboratory, Tongji Hospital of Tongji University, Shanghai 200065, China[3]School of Life Sciences and Technology, Tongji University, Shanghai 200092, China[4]These authors contributed equally to this work.[5]Authors to whom correspondence should be addressed.
CD146 has been regarded as a novel potential therapeutic target for multiple cancers. The aim of the study was to investigate the expression of CD146 in gastric cancer and evaluate its clinical-pathological and prognostic significance. The expression of CD146 and three epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, β-catenin and vimentin) was examined in 144 gastric cancers by immunohistochemistry. Fifty-nine cases (41.0%) were defined as positive for CD146 expression. We found that CD146 expression correlated positively with lymph node involvement and a poor prognosis, and retained an independent prognostic factor for gastric cancer patients. Furthermore, positive expression of CD146 was strongly associated with loss of the epithelial marker E-cadherin and acquisition of the expression of the mesenchymal markers nuclear β-catenin and vimentin. These findings suggest that CD146 might promote EMT and progression in gastric cancer, and thus may be a potential therapeutic target for patients with gastric cancers. View Full-Text
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外文
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中科院(CAS)分区：
出版当年[2011]版：
大类|4 区化学
小类|4 区化学综合
最新[2025]版：
大类|3 区生物学
小类|3 区生化与分子生物学3 区化学：综合
第一作者：
第一作者单位：[1]Department of General Surgery, Tongji Hospital of Tongji University, Shanghai 200065, China
推荐引用方式(GB/T 7714)：
Liu Wen-Fang,Ji Shu-Rong,Sun Jian-Jun,et al.CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer[J].International Journal of Molecular Sciences.2012,13(5):6399.doi:10.3390/ijms13056399.
APA：
Liu, Wen-Fang,Ji, Shu-Rong,Sun, Jian-Jun,Zhang, Yi,Liu, Zhong-Yan...&Zeng, Hua-Zong.(2012).CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer.International Journal of Molecular Sciences,13,(5)
MLA：
Liu, Wen-Fang,et al."CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer".International Journal of Molecular Sciences 13..5(2012):6399
