A new steroid, (3S,22R,24R)-stigmast-5-ene-3 beta,22 alpha-diol (1), together with ten known compounds, stigmast-5-ene-3 beta,7 alpha,22 alpha-triol (2), 24-ethylcholest-5-ene-3 beta,4 beta,22 alpha-triol (3), stigmast-5-ene-3 beta,7 alpha-diol (4) beta-sitosterol (5), 6-daucosterol (6), (1R,2R)-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol (7), (1S,2S)-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol (8), eugenol (9), methoxyeugenol (10), and methyl (E)-ferulate (11) were isolated from the stem barks of Cinnamomum wilsonii. The structure including the absolute configuration of 1 was determined by spectroscopic data interpretation and X-ray single-crystal diffraction analysis with Cu K alpha irradiation. Compounds 1 similar to 11 were evaluated for immunomodulatory activities against murine lymphocytes. 1, 5 and 6 significantly inhibited the proliferation of murine ConA-induced T cells, and 6 and 9 significantly inhibited the proliferation of LPS-induced murine B cells.
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China
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推荐引用方式(GB/T 7714)：
Wei Xialan,Shu Penghua,Liu Tingting,等.Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii[J].CHINESE JOURNAL OF ORGANIC CHEMISTRY.2013,33(6):1273-1278.
