详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Strategies to improve the migration of mesenchymal stromal cells in cell therapy

文献详情

资源类型：

作者：

单位： [1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Pharmacology and Toxicology, Wright State University School of Medicine, Dayton, Ohio 45345, USA

出处：

DOI：

ISSN：

关键词： MSCs migration cell therapy engraftment efficiency neurological disorder

摘要：

Mesenchymal stromal/stem cells (MSCs) are multipotent cells under consideration as a potential new therapy for a variety of inflammatory diseases including certain neurological disorders. It is generally thought that the efficacy of cell therapy in attenuating damage after ischemia, inflammation, or injury depends on the quantity of transplanted cells recruited to the target tissue. However, only a small number of systematically infused MSCs can effectively migrate to target sites, which significantly decreases the efficacy of exogenous cell-based therapy. In this review, we discuss specific factors influencing MSC migration, and summarize current strategies that effectively promote the motility of MSCs. In addition, we describe several protocols to improve the migration of stromal cells into the nervous system and, therefore, enhance the efficiency of engraftment as means of treating neurological disorders.

基金：

语种：

第一作者：

第一作者单位： [1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy [2]Can neurological soft signs and neurocognitive deficits serve as a combined endophenotype for Han Chinese with bipolar disorder? [3]Strategies to improve the migration of mesenchymal stromal cells in cell therapy [4]Stem cell therapy for amyotrophic lateral sclerosis [5]CAR T Cell Therapy for Hematological Malignancies [6]Androgen receptor promotes esophageal cancer cell migration and proliferation via matrix metalloproteinase 2 [7]Advances in Universal CAR-T Cell Therapy [8]Mesenchymal stromal cell therapy in ischemic stroke [9]A good response of refractory mantel cell lymphoma to haploidentical CAR T cell therapy after failure of autologous CAR T cell therapy [10]IP-10 enhances the amplification capacity and antitumor activity of CAR-T cells in vitro and could influence positive outcomes in MM patients treated with CAR-T cell therapy