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Biomaterials targeting the microenvironment for spinal cord injury repair: progression and perspectives

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单位： [1]Department of Neurosurgery, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China. [2]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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关键词： spinal cord injury spinal cord repair biomaterial scaffolds cell transplantation stem cell

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Spinal cord injury (SCI) disrupts nerve pathways and affects sensory, motor, and autonomic function. There is currently no effective treatment for SCI. SCI occurs within three temporal periods: acute, subacute, and chronic. In each period there are different alterations in the cells, inflammatory factors, and signaling pathways within the spinal cord. Many biomaterials have been investigated in the treatment of SCI, including hydrogels and fiber scaffolds, and some progress has been made in the treatment of SCI using multiple materials. However, there are limitations when using individual biomaterials in SCI treatment, and these limitations can be significantly improved by combining treatments with stem cells. In order to better understand SCI and to investigate new strategies for its treatment, several combination therapies that include materials combined with cells, drugs, cytokines, etc. are summarized in the current review.Copyright © 2024 Gao, Wang, Wu and Liu.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区神经科学

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第一作者单位： [1]Department of Neurosurgery, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.

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