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Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Zhang Qilun[1] * ; Shen Xuting[2] * ; Yuan Xin[2] * ; Huang Jing[2] ; Zhu Yaling[2] ; Zhu Tengteng[2] ; Zhang Tao[2] ; Wu Haibo[3] ; Wu Qian[4] ; Fan Yinguang[5] ; Ni Jing[5] ; Meng Leilei[2] ; He Anyuan[6] ; Shi Chaowei[7] ; Li Hao[7] ; Hu Qingsong[8] ; Wang Jian[9] ; Chang Cheng[9] ; Huang Fan[10] ; Li Fang[11] ; Chen Meng[12] ; Liu Anding[13] ; Ye Shandong[1] ; Zheng Mao[1] ; Fang Haoshu[2] ;
单位： [1]Laboratory of Diabetes, Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences andMedicine, University of Science and Technology of China, Hefei, Anhui 230001, China. [2]Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230000, China. [3]Department of Pathology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001,China. [4]Department of pathology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230011, China. [5]Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. [6]School of Life Sciences, AnhuiMedical University, Hefei, Anhui 230000, China. [7]Department of Chemistry, Center for BioAnalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale, School of Life Sciences,University of Science and Technology ofChina,Hefei,Anhui 230022,China. [8]Department ofHepatobiliary Surgery, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, China. [9]State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China. [10]Organ Transplantation Center, Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China. [11]Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022, China. [12]Graduate School of BengbuMedicalCollege, Bengbu, Anhui 233030, China. [13]Experimental Medicine Center,Tongji Hospital,TongjiMedical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China.
出处：
DOI： 10.1038/s41467-024-47553-5
ISSN：

摘要：
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides into LDs to prevent further peroxidation. Here we identify the upregulation of lipopolysaccharide-binding protein (LBP) and its trafficking through LDs as a mechanism for modulating LD homeostasis in response to oxidative stress. Our results suggest that LBP induces lipid accumulation by controlling lipid-redox homeostasis through its lipid-capture activity, sorting unsaturated triglycerides into LDs. N-acetyl-L-cysteine treatment reduces LBP-mediated triglycerides accumulation by phospholipid/triglycerides competition and Peroxiredoxin 4, a redox state sensor of LBP that regulates the shuttle of LBP from LDs. Furthermore, chronic stress upregulates LBP expression, leading to insulin resistance and obesity. Our findings contribute to the understanding of the role of LBP in regulating LD homeostasis and against cellular peroxidative injury. These insights could inform the development of redox-based therapies for alleviating oxidative stress-induced metabolic dysfunction.© 2024. The Author(s).

基金：
This research was supported by the National Science Foundation of China grants 81971875 (H.S.F.), 82071590 (A.D.L.), the Fundamental Research Funds for the Central Universities WK9110000194 (M.Z.), Special Project for Local Science and Technology Development Guided by Anhui Province 2017070802D147 (S.D.Y.) and Talent Training Program, School of Basic Medical Sciences, Anhui Medical University 2022YPJH102 (H.S.F.).
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外文
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出版当年[2023]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
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出版当年[2022]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]Laboratory of Diabetes, Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences andMedicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
共同第一作者：
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推荐引用方式(GB/T 7714)：
Zhang Qilun,Shen Xuting,Yuan Xin,et al.Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis[J].NATURE COMMUNICATIONS.2024,15(1):3213.doi:10.1038/s41467-024-47553-5.
APA：
Zhang Qilun,Shen Xuting,Yuan Xin,Huang Jing,Zhu Yaling...&Fang Haoshu.(2024).Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.NATURE COMMUNICATIONS,15,(1)
MLA：
Zhang Qilun,et al."Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis".NATURE COMMUNICATIONS 15..1(2024):3213

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