单位：[1]Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.[2]Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.[3]Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan 430060, China.[4]State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Recent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate the causal association between gut microbiota and biological age acceleration using the largest available gut microbiota GWAS summary data from the MiBioGen consortium and GWAS data on biological age acceleration. We further conducted sensitivity analysis using MR-PRESSO, MR-Egger regression, Cochran Q test, and reverse MR analysis. Streptococcus (IVW, β = 0.16, p = 0.0001) was causally associated with Bioage acceleration. Eubacterium (rectale group) (IVW, β = 0.20, p = 0.0190), Sellimonas (IVW, β = 0.06, p = 0.019), and Lachnospira (IVW, β = -0.18, p = 0.01) were suggestive of causal associations with Bioage acceleration, with the latter being protective. Actinomyces (IVW, β = 0.26, p = 0.0083), Butyricimonas (IVW, β = 0.21, p = 0.0184), and Lachnospiraceae (FCS020 group) (IVW, β = 0.24, p = 0.0194) were suggestive of causal associations with Phenoage acceleration. This Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
基金：
This work was supported by the Fundamental Research Funds for the Central Universities
(Grant No. 2042022kf1215), the Special Funds for Innovation in Scientific Research Program of
Zhongshan (Grant No. 2020AG024), the Clinical Research Project of Health Industry of Shanghai
Municipal Health Commission (Grant No. 202140407), the Key Disciplines Group Construction Project
of Pudong Health Bureau of Shanghai (Grant No. PWZxq2022-08), Chinese foundation for hepatitis
prevention and control-TianQing liver disease research fund subject (Grant No. TGQB20210109), the
Open Funds of Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang
Province (Grant No. KFJJ-202005, KFJJ-201907), and the Open Research Program of the State Key
Laboratory of Virology of China (Grant No. 2021KF002, 2021KF006).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|2 区生物学
小类|3 区微生物学
最新[2025]版：
大类|2 区生物学
小类|3 区微生物学
第一作者：
第一作者单位：[1]Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ye Chenglin,Li Zhiqiang,Ye Chun,et al.Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study[J].Microorganisms.2024,12(2):doi:10.3390/microorganisms12020370.
APA：
Ye Chenglin,Li Zhiqiang,Ye Chun,Yuan Li,Wu Kailang&Zhu Chengliang.(2024).Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study.Microorganisms,12,(2)
MLA：
Ye Chenglin,et al."Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study".Microorganisms 12..2(2024)
