单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China内科学系血液内科华中科技大学同济医学院附属同济医院[2]Chinese Acad Med Sci, Minist Educ, Key Lab Organ Transplantat, Wuhan, Peoples R China[3]Chinese Acad Med Sci, NHC Key Lab Organ Transplantat, Wuhan, Peoples R China[4]Chinese Acad Med Sci, Key Lab Organ Transplantat, Wuhan, Peoples R China[5]Immunotherapy Res Ctr Hematol Dis Hubei Prov, Wuhan, Peoples R China[6]Third Hosp Shanxi Med Univ, Shanxi Acad Med Sci, Tongji Shanxi Hosp, Dept Hematol,Shanxi Bethune Hosp, Taiyuan, Peoples R China[7]Shanxi Acad Med Sci, Shanxi Bethune Hosp, Sino German Joint Oncol Res Lab, Taiyuan, Peoples R China
Background: Plasmacytoid dendritic cells (pDCs), being a primary source of natural type I interferon (IFN-I), have pivotal roles in orchestrating the immune response. Typically, only less than 1% pDCs can be detected in the total bone marrow or peripheral blood nuclear cells. However, the uncontrollable proliferation of transformed pDCs is a remarkable characteristic of blastic plasmacytoid dendritic cell neoplasm (BPDCN). Recently, an abnormal amplification of pDCs in myeloid neoplasms has also been reported in MDS/AML patients (pDC-AML/MDS). This abnormal increase in pDCs could potentially promote disease progression. In this study, we utilized single-cell RNA-sequencing (scRNA-seq) to examine the characteristics of pDCs in pDC-AML.
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Xingcheng,Peng Juan,Li Chunrui,et al.Heterogeneity and Differentiation Patterns of pDC Cells in pDC-AML: A Novel Perspective from Single-Cell RNA Sequencing[J].BLOOD.2023,142:doi:10.1182/blood-2023-190826.
APA：
Yang, Xingcheng,Peng, Juan,Li, Chunrui,Zhang, Yicheng,Mao, Xia...&Wei, Jia.(2023).Heterogeneity and Differentiation Patterns of pDC Cells in pDC-AML: A Novel Perspective from Single-Cell RNA Sequencing.BLOOD,142,
MLA：
Yang, Xingcheng,et al."Heterogeneity and Differentiation Patterns of pDC Cells in pDC-AML: A Novel Perspective from Single-Cell RNA Sequencing".BLOOD 142.(2023)
医学