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Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets

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收录情况： ◇ SCIE

作者：
Ju Jie[1] * ; Li Zheng[1] ; Jia Xiaoqian[1] ; Peng Xiaoling[1] ; Wang Jihong[1] ; Gao Feng[1,*1] ;
单位： [1]Department of Anesthesiology and Pain Medicine,Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,and Wuhan Clinical Research Center for Geriatric Anesthesia,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
出处：
DOI： 10.1016/j.phrs.2024.107089
ISSN：

关键词： Interleukin-18 Chronic pain Neuropathic pain Cancer pain Central poststroke pain Polyneuropathy

摘要：
Chronic pain has been proven to be an independent disease, other than an accompanying symptom of certain diseases. Interleukin-18 (IL-18), a pro-inflammatory cytokine with pleiotropic biological effects, participates in immune modulation, inflammatory response, tumor growth, as well as the process of chronic pain. Compelling evidence suggests that IL-18 is upregulated in the occurrence of chronic pain. Antagonism or inhibition of IL-18 expression can alleviate the occurrence and development of chronic pain. And IL-18 is located in microglia, while IL-18R is mostly located in astrocytes in the spinal cord. This indicates that the interaction between microglia and astrocytes mediated by the IL-18/IL-18R axis is involved in the occurrence of chronic pain. In this review, we described the role and mechanism of IL-18 in different types of chronic pain. This review provides strong evidence that IL-18 is a potential therapeutic target in pain management.Copyright © 2024. Published by Elsevier Ltd.

基金：
This work was supported by the National Natural Science Foundation of China (grant numbers 81974168, 81771191 and 81471143).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 1 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2022]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2024]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2024版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]Department of Anesthesiology and Pain Medicine,Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,and Wuhan Clinical Research Center for Geriatric Anesthesia,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China
通讯作者：
通讯机构： [1]Department of Anesthesiology and Pain Medicine,Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health,and Wuhan Clinical Research Center for Geriatric Anesthesia,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [*1]Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Ave,Wuhan 430030,China
推荐引用方式(GB/T 7714)：
Ju Jie,Li Zheng,Jia Xiaoqian,et al.Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets[J].PHARMACOLOGICAL RESEARCH.2024,201:107089.doi:10.1016/j.phrs.2024.107089.
APA：
Ju Jie,Li Zheng,Jia Xiaoqian,Peng Xiaoling,Wang Jihong&Gao Feng.(2024).Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets.PHARMACOLOGICAL RESEARCH,201,
MLA：
Ju Jie,et al."Interleukin-18 in chronic pain: Focus on pathogenic mechanisms and potential therapeutic targets".PHARMACOLOGICAL RESEARCH 201.(2024):107089

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