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Apnea Testing Practice to Increase Baseline PaCO2 and Frequency of Blood Gas Analyses

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单位： [1]Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China. [2]Department of Neurology, Army Medical Center of PLA, Chongqing, China. [3]Neurological Intensive Care Unit, First Affiliated Hospital of Anhui Medical University, Zhengzhou, China. [4]Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. [5]First Hospital of Jilin University, Changchun, China. [6]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [7]First People's Hospital of Yunnan Province, Kunming, Yunnan Province, China. [8]Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.

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关键词： braindeath apneatesting positivityrate safety multicenterstudy

摘要：

To study the influence of the initial partial pressure of carbon dioxide (PaCO2) and frequency of blood gas analyses on the positivity rate and safety of apnea testing (AT).A prospective multicenter cohort study.Seven teaching hospitals.A total of 55 patients who underwent AT.Patients were divided into 2 groups according to their initial PaCO2-the experimental group (≥40 mmHg, 27 patients) and the control group (<40 mmHg, 28 patients). Blood gas analysis was performed at 3, 5, and 8 minutes, and vital signs were taken. AT results and complications were compared between the groups.The initial PaCO2 of the experimental group was 42.8 ± 2.2 mmHg v 36.4 ± 2.9 mmHg in the controls. The AT positivity rate was 100%. The experimental group needed less time to reach the target PaCO2 than the control group (4.07 ± 1.27 minutes v 5.68 ± 2.06 minutes; p = 0.001). Twenty-six patients (96.3%) in the experimental group reached the target PaCO2 in 5 minutes v 17 in the control group (60.7%) (p = 0.001). Seven patients (12.7%) were unable to complete 8-minute disconnection due to hypotension. The experimental group had a slightly lower incidence of hypotension than the control group, but there was no statistical difference (7.4% v 17.9%, p = 0.245).Increasing the baseline PaCO2 and doing more blood gas analyses can significantly shorten the time needed for AT and improve the AT positivity rate.Copyright © 2023 Elsevier Inc. All rights reserved.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区麻醉学 4 区外周血管病 4 区心脏和心血管系统 4 区呼吸系统

最新[2025]版：

大类 | 4 区医学

小类 | 4 区麻醉学 4 区心脏和心血管系统 4 区外周血管病 4 区呼吸系统

第一作者：

第一作者单位： [1]Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.

通讯作者：

通讯机构： [8]Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China. [*1]Department of Neurology, Xuanwu Hospital Capital Medical University, No.45 Changchun Street, Xicheng District, 100053 Beijing.

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Apnea Testing Practice to Increase Baseline PaCO2 and Frequency of Blood Gas Analyses

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