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Smooth Pursuit and Reflexive Saccade in Discriminating Multiple-System Atrophy With Predominant Parkinsonism From Parkinson's Disease

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收录情况： ◇ SCIE

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单位： [1]Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China. [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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关键词： Parkinson’s disease multiple-system atrophy saccades smooth pursuit

摘要：

Performing the differential diagnosis of Parkinson's disease (PD) and multiple-system atrophy of parkinsonian type (MSA-P) is challenging. The oculomotor performances of patients with PD and MSA-P were investigated to explore their potential role as a biomarker for this differentiation.Reflexive saccades and smooth pursuit were examined in 56 patients with PD and 34 with MSA-P in the off-medication state.Patients with PD and MSA-P had similar oculomotor abnormalities of prolonged and hypometric reflexive saccades. The incidence rates of decreased reflexive saccadic velocity and saccadic smooth pursuit were significantly higher in MSA-P than in PD (p<0.05 for both). Multiple logistic regression analysis indicated that slowed reflexive saccades (odds ratio [OR]=8.14, 95% confidence interval [CI]=1.45-45.5) and saccadic smooth pursuit (OR=5.27, 95% CI=1.24-22.43) were significantly related to MSA-P.The distinctive oculomotor abnormalities of saccadic smooth pursuit and slowed reflexive saccades in MSA-P may serve as useful biomarkers for discriminating MSA-P from PD.Copyright © 2024 Korean Neurological Association.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 4 区临床神经病学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

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出版当年[2022]版：

Q3 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY

影响因子： 3 最新[2023版] 2.8 最新五年平均 3.1 出版当年[2022版] 3.3 出版当年五年平均 2.566 出版前一年[2021版] 3 出版后一年[2023版]

第一作者：

第一作者单位： [1]Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China. [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

通讯作者：

通讯机构： [1]Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China. [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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Smooth Pursuit and Reflexive Saccade in Discriminating Multiple-System Atrophy With Predominant Parkinsonism From Parkinson's Disease

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