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Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma

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WOS体系：
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收录情况： ◇ SCIE ◇ 自然指数

作者：
Yu Jingjing[1,2,3] * ; Zhu Peng[1,3] * ; Shi Linlin[2,7] * ; Gao Na[8] * ; Li Yani[1,3] ; Shu Chang[1,3] ; Xu Ying[5] ; Yu Ying[7] ; He Junqing[5] ; Guo Dingming[5] ; Zhang Xiaoman[7] ; Wang Xiangfeng[5] ; Shao Sirui[5] ; Dong Wei[1,3] ; Wang Yuwei[1,3] ; Zhang Wei[1,3] ; Zhang Wanguang[1,3] ; Chen Wei-Hua[6,9] ; Chen Xiaoping[1,3] ; Liu Zhi[5,10] ; Yang Xiangliang[2,4,5] ; Zhang Bixiang[1,3] ;
单位： [1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China [3]Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [4]Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China [5]Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China [6]Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center for Artificial Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China [7]Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang 471003, China [8]Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China [9]Institution of Medical Artificial Intelligence, Binzhou Medical University, Yantai 264003, China [10]Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China
出处：
DOI： 10.1016/j.chom.2023.11.011
ISSN：

摘要：
Timely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts and identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC patients with delayed recovery to mice similarly impacted recovery time post hepatectomy. However, oral gavage of B. longum improved liver function and repair in these mice. In a clinical trial of HCC patients, orally administering a probiotic bacteria cocktail containing B. longum reduced the rates of delayed recovery, shortened hospital stays, and improved overall 1-year survival. These benefits, attributed to diminished liver inflammation, reduced liver fibrosis, and hepatocyte proliferation, were associated with changes in key metabolic pathways, including 5-hydroxytryptamine, secondary bile acids, and short-chain fatty acids. Our findings propose that gut microbiota modulation can enhance LFR, thereby improving postoperative outcomes for HCC patients.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
This study was supported by the National Key Research and Development Program of China to X.Y. and B.Z. (2018YFA0208900), W.-H.C. and Z.L. (2019YFA0905600), National Natural Science Foundation of China (82073796, 81874189, 82373052, and 82302966), Chen Xiao-ping Foundation for the Development of Science and Technology of Hubei Province under grant (CXPJJH121003-2105), Key R&D and Promotion Projects of Henan Province (222102310115), Medical Science and Technology Research Projects of Henan Province (SBGJ202102199), and Youth Talent Project (2022HLTJ01).
语种：
外文
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WOS：
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 微生物学 1 区 寄生虫学 1 区 病毒学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 微生物学 1 区 寄生虫学 1 区 病毒学
JCR分区：
出版当年[2022]版：
Q1 MICROBIOLOGY Q1 PARASITOLOGY Q1 VIROLOGY
最新[2024]版：
Q1 MICROBIOLOGY Q1 PARASITOLOGY Q1 VIROLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China [3]Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
共同第一作者：
通讯作者：
通讯机构： [1]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China [3]Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [4]Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China [5]Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China [6]Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-Imaging, Center for Artificial Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China [9]Institution of Medical Artificial Intelligence, Binzhou Medical University, Yantai 264003, China [10]Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China
推荐引用方式(GB/T 7714)：
Yu Jingjing,Zhu Peng,Shi Linlin,et al.Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma[J].CELL HOST & MICROBE.2024,32(1):doi:10.1016/j.chom.2023.11.011.
APA：
Yu Jingjing,Zhu Peng,Shi Linlin,Gao Na,Li Yani...&Zhang Bixiang.(2024).Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma.CELL HOST & MICROBE,32,(1)
MLA：
Yu Jingjing,et al."Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma".CELL HOST & MICROBE 32..1(2024)

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