单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Div Cardiovasc Surg,1095 Jiefang Ave,Wuhan 430030,Peoples R China华中科技大学同济医学院附属同济医院[2]Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China[3]Chinese Acad Med Sci, Key Lab Organ Transplantat, Minist Educ, Wuhan, Hubei, Peoples R China[4]Chinese Acad Med Sci, NHC Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China[5]Chinese Acad Med Sci, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China[6]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Inst Organ Transplantat,Wuhan,Hubei,Peoples R China器官移植研究所华中科技大学同济医学院附属同济医院器官移植
Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) is known to be involved in the deposition of the di- and tri-methyl marks on H3K9 (H3K9me2 and H3K9me3), which are associated with transcription repression. SETDB1 exerts an essential role in the silencing of endogenous retroviruses (ERVs) in embryonic stem cells (mESCs) by tri-methylating H3K9 (H3K9me3) and interacting with DNA methyltransferases (DNMTs). Additionally, SETDB1 is engaged in regulating multiple biological processes and diseases, such as ageing, tumors, and inflammatory bowel disease (IBD), by methylating both histones and non-histone proteins. In this review, we provide an overview of the complex biology of SETDB1, review the upstream regulatory mechanisms of SETDB1 and its partners, discuss the functions and molecular mechanisms of SETDB1 in cell fate determination and stem cell, as well as in tumors and other diseases. Finally, we discuss the current challenges and prospects of targeting SETDB1 for the treatment of different diseases, and we also suggest some future research directions in the field of SETDB1 research.
基金：
This work was supported by grants from the National Natural Science Foundation
of China (No. 82070306, No. 81873456, and No. 82170502).
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Div Cardiovasc Surg,1095 Jiefang Ave,Wuhan 430030,Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Div Cardiovasc Surg,1095 Jiefang Ave,Wuhan 430030,Peoples R China[3]Chinese Acad Med Sci, Key Lab Organ Transplantat, Minist Educ, Wuhan, Hubei, Peoples R China[4]Chinese Acad Med Sci, NHC Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China[5]Chinese Acad Med Sci, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China[6]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Inst Organ Transplantat,Wuhan,Hubei,Peoples R China
推荐引用方式(GB/T 7714)：
Luo Hanshen,Wu Xingliang,Zhu Xue-Hai,et al.The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease[J].EPIGENETICS & CHROMATIN.2023,16(1):doi:10.1186/s13072-023-00519-1.
APA：
Luo, Hanshen,Wu, Xingliang,Zhu, Xue-Hai,Yi, Xin,Du, Dunfeng&Jiang, Ding-Sheng.(2023).The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease.EPIGENETICS & CHROMATIN,16,(1)
MLA：
Luo, Hanshen,et al."The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease".EPIGENETICS & CHROMATIN 16..1(2023)
