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Recent advances in enterovirus A71 infection and antiviral agents

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收录情况： ◇ SCIE

作者：
Wei Yanhong[1] * ; Liu Huihui[1] ; Hu Da[1] ; He Qun[1] ; Yao Chenguang[1] ; Li Hanluo[1] ; Hu Kanghong[1] ; Wang Jun[2] ;
单位： [1]National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, Hubei University of Technology, No 28, Nanli Road, Wuhan 430068, China [2]Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
出处：
DOI： 10.1016/j.labinv.2023.100298
ISSN：

关键词： Enterovirus A71 Antiviral agents Receptor Viral replication Signal pathway

摘要：
Enterovirus A71 (EV-A71) is one of the major causative agents of hand-foot-and-mouth disease (HFMD) that majorly affects children. Most of the time, HFMD is a mild disease but can progress to severe complications such as meningitis, brain stem encephalitis, acute flaccid paralysis (AFP) and even death. HFMD caused by EV-A71 has emerged as an acutely infectious disease of highly pathogenic potential in the Asia-Pacific region. In this review, we introduced the properties and life cycle of EV-A71, the pathogenesis and the pathophysiology of EV-A71 infection, including: tissue tropism and host range of virus infection, the diseases caused by the virus, as well as the genes and host cell immune mechanisms of major diseases caused by EV71 infection, such as encephalitis and neurological pulmonary edema. At the same time, clinicopathological characteristics of EV71 infection were introduced. There is currently no specific medication for EV-A71 infection, highlighting the urgency and significance of developing suitable anti-EV-A71 agents. This overview also summarizes the targets of existing anti-EV-A71 agents, including virus entry, translation, polyprotein processing, replication, assembly and release; interferons (IFNs); interleukin (IL); the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt) signaling pathways; the oxidative stress pathway; and the ubiquitin-proteasome system, et al. Furthermore, it overviews the effects of natural products, monoclonal antibodies, and RNA interference against EV-A71. It also discusses issues limiting the research of antiviral drugs. This review is a systematic and comprehensive summary of the mechanism and pathological characteristics of EV71 infection, the latest progress of existing anti-EV-A71 agents. It would provide better understanding and guidance for the research and application of EV71 infection and antiviral inhibitors.Copyright © 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights reserved.

基金：
This research was funded by the Key R&D Project of Hubei Province (Social Development), China (2022BCA018) and the Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), China (2022KF16) to K.H.; the Open Project Funding of the Key Laboratory of Fermentation Engineering (Ministry of Education) (094/1200901) to Y. W. and the National Natural Science Foundation,China (81700013) to J.W
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验 2 区 病理学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验 2 区 病理学
JCR分区：
出版当年[2022]版：
Q1 PATHOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q1 PATHOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2024版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者单位： [1]National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Sino-German Biomedical Center, Hubei University of Technology, No 28, Nanli Road, Wuhan 430068, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wei Yanhong,Liu Huihui,Hu Da,et al.Recent advances in enterovirus A71 infection and antiviral agents[J].LABORATORY INVESTIGATION.2024,104(2):100298.doi:10.1016/j.labinv.2023.100298.
APA：
Wei Yanhong,Liu Huihui,Hu Da,He Qun,Yao Chenguang...&Wang Jun.(2024).Recent advances in enterovirus A71 infection and antiviral agents.LABORATORY INVESTIGATION,104,(2)
MLA：
Wei Yanhong,et al."Recent advances in enterovirus A71 infection and antiviral agents".LABORATORY INVESTIGATION 104..2(2024):100298

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