单位：[1]Department of Respiratory and Critical Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.内科学系呼吸内科华中科技大学同济医学院附属同济医院[2]The Center for Biomedical Research,National Health Committee (NHC) Key Laboratory of Respiratory Disease,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.内科学系科研平台呼吸内科生物医学研究中心生物医学中心华中科技大学同济医学院附属同济医院[3]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.器官移植研究所华中科技大学同济医学院附属同济医院器官移植[4]Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China.
Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology with limited treatment options. The role of the immune system in IPF has received increasing attention. Uncontrolled immune responses drive the onset and progression of IPF. This article provides an overview of the role of innate immune cells (including macrophages, neutrophils, mast cells, eosinophils, dendritic cells, nature killer cells, nature kill cells and γδ T cells) and adaptive immune cells (including Th1 cells, Th2 cells, Th9 cells, Th17 cells, Th22 cells, cytotoxic T cells, B lymphocytes and Treg cells) in IPF. In addition, we review the current status of pharmacological treatments for IPF and new developments in immunotherapy. A deeper comprehension of the immune system's function in IPF may contribute to the development of targeted immunomodulatory therapies that can alter the course of the disease.
基金：
This work was supported by National Natural Science Foundation of China (No. 81470252)
to Tao Wang.
第一作者单位：[1]Department of Respiratory and Critical Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.[2]The Center for Biomedical Research,National Health Committee (NHC) Key Laboratory of Respiratory Disease,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.
通讯作者：
通讯机构：[1]Department of Respiratory and Critical Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.[2]The Center for Biomedical Research,National Health Committee (NHC) Key Laboratory of Respiratory Disease,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.[3]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China.[4]Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China.
推荐引用方式(GB/T 7714)：
Xu Yahan,Lan Peixiang,Wang Tao.The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis[J].MEDICINA-LITHUANIA.2023,59(11):doi:10.3390/medicina59111984.
APA：
Xu Yahan,Lan Peixiang&Wang Tao.(2023).The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis.MEDICINA-LITHUANIA,59,(11)
MLA：
Xu Yahan,et al."The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis".MEDICINA-LITHUANIA 59..11(2023)
