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Regulation of biofilm formation in Klebsiella pneumoniae

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收录情况： ◇ SCIE

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单位： [1]Department and Institute of Infectious Disease,Tongji Hospital,Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease,Huazhong University of Science and Technology,Wuhan,China.

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关键词： Klebsiella pneumoniae biofilm capsule fimbriae factors

摘要：

Klebsiella pneumoniae is an important Gram-negative opportunistic pathogen that is responsible for a variety of nosocomial and community-acquired infections. Klebsiella pneumoniae has become a major public health issue owing to the rapid global spread of extensively-drug resistant (XDR) and hypervirulent strains. Biofilm formation is an important virulence trait of K. pneumoniae. A biofilm is an aggregate of microorganisms attached to an inert or living surface by a self-produced exo-polymeric matrix that includes proteins, polysaccharides and extracellular DNA. Bacteria within the biofilm are shielded from antibiotics treatments and host immune responses, making it more difficult to eradicate K. pneumoniae-induced infection. However, the detailed mechanisms of biofilm formation in K. pneumoniae are still not clear. Here, we review the factors involved in the biofilm formation of K. pneumoniae, which might provide new clues to address this clinical challenge.Copyright © 2023 Li and Ni.

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出版当年[2022]版：

大类 | 2 区

生物学

小类 | 2 区微生物学

最新[2025]版：

大类 | 2 区生物学

小类 | 3 区微生物学

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出版当年[2021]版：

Q1 MICROBIOLOGY

最新[2023]版：

Q2 MICROBIOLOGY

影响因子： 4 最新[2023版] 5.1 最新五年平均 6.064 出版当年[2021版] 6.843 出版当年五年平均 5.64 出版前一年[2020版] 5.2 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department and Institute of Infectious Disease,Tongji Hospital,Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease,Huazhong University of Science and Technology,Wuhan,China.

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