详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

L-lysine supplementation attenuates experimental autoimmune hepatitis in a chronic murine model

78| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China [2]Department of Gastroenterology, Shangrao People’s Hospital, Shangrao 334000,Jiangxi Province, China

出处：

DOI：

ISSN：

关键词： L-lysine autoimmune hepatitis oxidative stress infiltration

摘要：

The incidence of autoimmune hepatitis (AIH) has increased significantly worldwide. The present study aims to explore the protective effect of L-lysine supplementation against AIH and to investigate its potential underlying mechanisms. A chronic experimental AIH mouse model was established by repeated tail vein injection of human cytochrome P450 2D6 (CYP2D6) plasmid. Starting from day 14 of the modeling, mice in the CYP2D6-AIH +L-lysine group were given 200 μl of purified water containing 10 mg/kg L-lysine by gavage until day27, once a day, and mice in the healthy control group and model group were given an equal volume of purified water by gavage. Our results showed that L-lysine supplementation partially reversed the liver injury mediated by CYP2D6 overexpression. These effects were consistent with the restraining impacts of L-lysine supplementation on decreasing pro-inflammatory cytokines expression level and CD4+ and CD8+ T lymphocytes infiltration, as well as curbing hepatic oxidative stress. Furthermore, L-lysine supplement relieved liver fibrosis in the context of AIH. In conclusion, L-lysine supplementation attenuates CYP2D6-induced immune liver injury in mice, which may serve as a novel nutrition support approach for AIH.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 4 区农林科学

小类 | 4 区兽医学 4 区动物学

最新[2025]版：

大类 | 3 区农林科学

小类 | 3 区兽医学 3 区动物学

JCR分区：

出版当年[2022]版：

Q1 VETERINARY SCIENCES Q1 ZOOLOGY

最新[2023]版：

Q1 VETERINARY SCIENCES Q1 ZOOLOGY

影响因子： 2.2 最新[2023版] 2.1 最新五年平均 2.4 出版当年[2022版] 2.3 出版当年五年平均 1.798 出版前一年[2021版] 2.2 出版后一年[2023版]

第一作者：

第一作者单位： [1]Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Hepatic SATB1 exacerbates autoimmune hepatitis by regulating macrophage infiltration [2]Recent Advances in Nanomaterials for the Treatment of Acute Kidney Injury [3]Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic β-cells [4]Fenugreek lactone attenuates palmitate-induced apoptosis and dysfunction in pancreatic beta-cells [5]Sophoricoside attenuates autoimmune‑mediated liver injury through the regulation of oxidative stress and the NF‑κB signaling pathway [6]Oxidative stress and distinct cell death [7]IL-17 contributes to autoimmune hepatitis [8]Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6 [9]Melatonin resists oxidative stress-induced apoptosis in nucleus pulposus cells [10]The Role of Nanomaterials in Stroke Treatment: Targeting Oxidative Stress