Introduction: Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder caused by the BCR-ABL chimeric tyrosine kinase. Vincristine (VCR) is widely used in leukemia therapy but is hindered by multidrug resistance (MDR).Methods: We prepared DNA nanoflower via self-assembly for the delivery of VCR and P-glycoprotein small interfering RNA (P-gp siRNA).Results and Discussion: The as-prepared nanoflower had a floriform shape with high loading efficiency of VCR (80%). Furthermore, the nanoflower could deliver VCR and P-gp siRNA into MDR CML cells and induce potent cytotoxicity both in vitro and in vivo, thus overcoming MDR of CML. Overall, this nanoflower is a promising tool for resistant CML therapy.
基金：
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work is supported by the National Natural Science Foundation of China (82202532 and 82102080), China Postdoctoral Science Foundation [82102080, 2022M711528]; National Natural Science Foundation of China; China Postdoctoral Science Foundation; [82202532]
第一作者单位：[1]Hainan Med Univ, Sch Pharm, Hainan Prov Key Lab Res & Dev Trop Herbs, Haikou Key Lab Li Nationality Med,Key Lab Trop Tra, Haikou, Peoples R China
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推荐引用方式(GB/T 7714)：
Zhao Pengxuan,Zhong Yeteng,Pan Pengcheng,et al.DNA self-assembly nanoflower reverse P-glycoprotein mediated drug resistance in chronic myelogenous leukemia therapy[J].FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.2023,11:doi:10.3389/fbioe.2023.1265199.
APA：
Zhao, Pengxuan,Zhong, Yeteng,Pan, Pengcheng,Zhang, Shasha,Tian, Yu...&Wu, Tiantian.(2023).DNA self-assembly nanoflower reverse P-glycoprotein mediated drug resistance in chronic myelogenous leukemia therapy.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,11,
MLA：
Zhao, Pengxuan,et al."DNA self-assembly nanoflower reverse P-glycoprotein mediated drug resistance in chronic myelogenous leukemia therapy".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 11.(2023)
