In recent years, cavities have grown increasingly prevalent in both children and adults. The destruction of teeth is caused by cariogenic bacteria that produce or promote tooth decay. Recent studies on dental caries have highlighted the importance of herbal medications. The objective of this research was to assess the antibacterial activity of ethanolic extracts of Curcuma amada rhizome against Streptococcus mutans, Streptococcus oralis, and Lactobacillus acidophilus. In contrast to antibiotics, the rhizome extract of Curcuma amada shown significant anti-caries action against Streptococcus mutans, Streptococcus oralis, and Lactobacillus acidophilus. Oral pathogen Streptococci sp. was shown to be strongly inhibited in its biofilm production by this compound. The aforementioned findings shown that Curcuma amada rhizome extract had anti-caries action by inhibiting the development of Streptococcal dental caries.