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Individual and joint associations of urinary phthalate metabolites with polycystic ovary and polycystic ovary syndrome: Results from the TREE cohort

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WOS体系：
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收录情况： ◇ SCIE

作者：
Zhang Min[1,2] * ; Liu Chong[1,2] ; Yuan Xiao-Qiong[3] ; Cui Fei-Peng[1,2] ; Miao Yu[1,2] ; Yao Wen[3] ; Qin Dan-Yu[3] ; Deng Yan-Ling[1,2] ; Chen Pan-Pan[1,2] ; Zeng Jia-Yue[1,2] ; Liu Xiao-Ying[1,2] ; Wu Yang[1,2] ; Li Cheng-Ru[1,2] ; Lu Wen-Qing[1,2] ; Li Yu-Feng[3] ; Zeng Qiang[1,2] ;
单位： [1]Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [2]Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [3]Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, Hubei, PR China
出处：
DOI： 10.1016/j.etap.2023.104233
ISSN：

关键词： Phthalates Polycystic ovary Polycystic ovary syndrome Phthalate metabolite mixture

摘要：
Phthalates are widespread endocrine disrupting chemicals that adversely affect female reproductive health. We aimed to investigate the individual and joint associations of phthalate exposures measured by repeated urinary metabolites with polycystic ovary (PCO) and polycystic ovary syndrome (PCOS) (96 PCO cases, 96 PCOS cases and 370 controls). In single-pollutant analyses, mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP) and the sum of di(2-ethylhexyl) phthalate (∑DEHP) were associated with increased prevalence of PCO. Mono(2-ethylhexyl) phthalate (MEHP), MBzP and ∑DEHP were associated with elevated prevalence of PCOS. In multiple-pollutant analyses, one-quartile increase of weighted quantile sum index in phthalate metabolite mixtures was associated with increased prevalence of PCO and PCOS, and MBzP was the most major contributor. Our findings suggest a potential role for phthalate exposures, both individually and in mixtures, in the development of PCO and PCOS.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This work was supported by the Fundamental Research Funds for the Central Universities (No. YCJJ202201025) and the National Natural Science Foundation of China (No. 81872585).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 环境科学与生态学
小类 | 2 区 毒理学 3 区 环境科学 3 区 药学
最新[2025]版：
大类 | 3 区 环境科学与生态学
小类 | 2 区 毒理学 3 区 环境科学 3 区 药学
JCR分区：
出版当年[2021]版：
Q1 PHARMACOLOGY & PHARMACY Q1 TOXICOLOGY Q2 ENVIRONMENTAL SCIENCES
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q1 TOXICOLOGY Q2 ENVIRONMENTAL SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [2]Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
通讯作者：
通讯机构： [1]Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China [2]Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
推荐引用方式(GB/T 7714)：
Zhang Min,Liu Chong,Yuan Xiao-Qiong,et al.Individual and joint associations of urinary phthalate metabolites with polycystic ovary and polycystic ovary syndrome: Results from the TREE cohort[J].ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY.2023,102:doi:10.1016/j.etap.2023.104233.
APA：
Zhang Min,Liu Chong,Yuan Xiao-Qiong,Cui Fei-Peng,Miao Yu...&Zeng Qiang.(2023).Individual and joint associations of urinary phthalate metabolites with polycystic ovary and polycystic ovary syndrome: Results from the TREE cohort.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,102,
MLA：
Zhang Min,et al."Individual and joint associations of urinary phthalate metabolites with polycystic ovary and polycystic ovary syndrome: Results from the TREE cohort".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 102.(2023)

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