详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Cancer-associated fibroblasts: Just on the opposite side of antitumour immunity?

70| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China

出处：

DOI：

ISSN：

关键词： Cancer-associated fibroblasts Antitumour immunity Immune activation Tumour microenvironment CAF-targeted therapy Tertiary lymphatic structures

摘要：

The tumour microenvironment (TME) is critical for the initiation, progression, and metastasis of tumours, and cancer-associated fibroblasts (CAFs) are the most dominant cells and have attracted interest as targets for cancer therapy among the stromal components within the TME. Currently, most of the identified CAF subpopulations are believed to exhibit suppressive effects on antitumour immunity. However, accumulating evidence indicates the presence of immunostimulatory CAF subpopulations, which play an important role in the maintenance and amplification of antitumour immunity, in the TME. Undoubtedly, these findings provide novel insights into CAF heterogeneity. Herein, we focus on summarizing CAF subpopulations that promote antitumour immunity, the surface markers of these populations, and possible immunostimulatory mechanisms in the context of recent advances in research on CAF subpopulations. In addition, we discuss the possibility of new therapies targeting CAF subpopulations and conclude with a brief description of some prospective avenues for CAF research.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区免疫学 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区免疫学

JCR分区：

出版当年[2021]版：

Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

最新[2024]版：

Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 4.7 最新[2024版] 5 最新五年平均 5.714 出版当年[2021版] 5.597 出版当年五年平均 4.932 出版前一年[2020版] 5.6 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China

通讯作者：

通讯机构： [1]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China [*1]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Blvd,Wuhan 430030,China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts [2]Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer [3]Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype [4]Cancer-associated fibroblasts endow stem-like qualities to liver cancer cells by modulating autophagy [5]Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy [6]Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts [7]Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling [8]Breast Cancer Associated Fibroblasts Promote MCF-7 Invasion in vitro by Secretion of HGF [9]乳腺癌相关成纤维细胞的分离培养及鉴定 [10]川崎病动物模型及其发病机制研究进展